Immunization of livestock with DNA vaccines: current studies and future prospects

Early studies using DNA immunization suggest the potential benefits of this form of immunization including: long-lived immunity, a broad spectrum of immune responses (both cell-mediated immunity and humoral responses) and the simultaneous induction of immunity to a variety of pathogens through the u...

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Bibliographic Details
Published in:Vaccine 2001-03, Vol.19 (17), p.2474-2479
Main Authors: van Drunen Littel-van den Hurk, S., Loehr, B.I., Babiuk, L.A.
Format: Article
Language:English
Subjects:
Animal Diseases - immunology
Animal Diseases - prevention & control
Animals
Animals, Domestic
Antibodies, Viral - blood
Biolistics
Biological and medical sciences
Biotechnology
Cattle
Cytokine-encoding plasmids
DNA immunization
Fundamental and applied biological sciences. Psychology
gD-expressing plasmid
Health. Pharmaceutical industry
Herpesviridae Infections - immunology
Herpesviridae Infections - prevention & control
Herpesviridae Infections - veterinary
Herpesvirus 1, Bovine - genetics
Herpesvirus 1, Bovine - immunology
Industrial applications and implications. Economical aspects
Major histocompatibility antigens
Production of active biomolecules
tgD-expressing plasmid
Vaccination - methods
Vaccination - veterinary
Vaccines, DNA - administration & dosage
Vaccines, DNA - pharmacology
Vaccins
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Summary:Early studies using DNA immunization suggest the potential benefits of this form of immunization including: long-lived immunity, a broad spectrum of immune responses (both cell-mediated immunity and humoral responses) and the simultaneous induction of immunity to a variety of pathogens through the use of multivalent vaccines. Using marine and cow models, we studied methods to enhance and direct the immune response to polynucleotide vaccines. We demonstrated the ability to modulate the magnitude and direction of the immune response by co-administration of plasmid encoded cytokines and antigen. Also, we clearly demonstrated that the cellular components (cytosolic, membrane-anchored, or extracellular) to which the expressed antigen is delivered determines the types of immune responses induced. Since induction of immunity at mucosal surfaces (route of entry for many pathogens) is critical to prevent infection, various methods of delivering polynucleotide vaccines to animals including mucosal surfaces have been attempted and are described as future prospects for improving immune responses by DNA vaccination.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(00)00476-X