Homing markers for atherosclerosis: applications for drug delivery, gene delivery and vascular imaging

Endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. Pro-inflammatory cytokines such as interleukin-1β and tumour necrosis factor α activate endothelial cells changing their resting phenotype to become pro-adhesive, pro-thrombotic and pro-atherogenic. Phage display in v...

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Bibliographic Details
Published in:FEBS letters 2001-03, Vol.492 (1), p.73-77
Main Authors: Houston, Parul, Goodman, Jo, Lewis, Alan, Campbell, Callum J, Braddock, Martin
Format: Article
Language:English
Subjects:
Animals
Arteries - metabolism
Arteriosclerosis - metabolism
Arteriosclerosis - pathology
Arteriosclerosis - therapy
Atherosclerosis
Bacteriophages - genetics
Binding Sites
Binding, Competitive
Disease Models, Animal
Drug delivery
Drug Delivery Systems
Gene delivery
Gene Transfer Techniques
Homing markers
Kidney - metabolism
Mice
Mice, Knockout
Organ Specificity
Peptide Library
Peptides - metabolism
Receptors, LDL - deficiency
Receptors, LDL - genetics
Receptors, LDL - metabolism
Sequence Analysis, Protein
Vascular imaging
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Summary:Endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. Pro-inflammatory cytokines such as interleukin-1β and tumour necrosis factor α activate endothelial cells changing their resting phenotype to become pro-adhesive, pro-thrombotic and pro-atherogenic. Phage display in vivo biopanning has been used to identify peptide sequences that home to diseased regions of the vessel wall in low density lipoprotein receptor (LDLr) knockout mice. In LDLr knockout mice, peptide sequence determinants exhibiting organ specificity have been isolated. These sequences have applications for gene delivery, drug delivery and for improving contrast agents for vascular imaging.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(01)02191-3