Body Temperature Dependency of Gastric Regional Blood Flow, Acid Secretion and Ulcer Formation in Restraint and Water-Immersion Stressed Rats

The effect of water temperature during restraint and water-immersion stress (RWIS) on gastric regional blood flow, acid secretion and ulcer formation were compared to those of restraint stress (RS) alone in rats. RS had no effect on the gastric regional blood flow. In contrast, the gastric regional...

Full description

Saved in:
Bibliographic Details
Published in:Japanese Journal of Pharmacology 1986, Vol.40(4), pp.501-504
Main Authors: ARAI, Iwao, MURAMATSU, Makoto, AIHARA, Hironaka
Format: Article
Language:eng ; jpn
Subjects:
Animals
Biological and medical sciences
Body Temperature
Gastric Acid - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Immersion
Male
Medical sciences
Other diseases. Semiology
Rats
Rats, Inbred Strains
Regional Blood Flow
Restraint, Physical
Stomach - blood supply
Stomach Ulcer - etiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Stress, Psychological - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of water temperature during restraint and water-immersion stress (RWIS) on gastric regional blood flow, acid secretion and ulcer formation were compared to those of restraint stress (RS) alone in rats. RS had no effect on the gastric regional blood flow. In contrast, the gastric regional blood flow was significantly decreased by RWIS. A water temperature dependent reduction of gastric regional blood flow induced by RWIS was observed between 20°C and 30°C. The decrease in gastric regional blood flow for RWIS rats was related to a lowering of the body temperature, which almost coincided with the temperature of water for the immersion. The gastric acid output was not influenced by RS. However, RWIS significantly increased the gastric acid output. The temperature of water in order of increasing acid output induced by RWIS was 25°C>30°C>20°C. Little ulcer formation was found in RS rats, while exposure to RWIS caused marked ulceration. The temperature of water in order of severity of ulceration by RWIS was 25°C>20°C>30°C. The severity of ulceration was not related to the decrease in gastric regional blood flow or increase of acid output, but was correlated to the ratio of the gastric blood flow/the acid output. These findings suggest that the decrease of gastric regional blood flow is in good agreement with the fall of body temperature, and the combined effects of the gastric blood flow and the acid secretion are involved in the ulceration caused by RWIS.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.40.501