Coagulation, Fibrinolysis and Platelet P-selectin Expression in Peripheral Vascular Disease

Objectives: to examine coagulation, fibrinolysis, and platelet activity in patients with peripheral vascular disease (PVD). Design: fifty consecutive PVD patients and 50 healthy volunteers. (Prospective comparative study.) Materials and methods: P-selectin expression in non-fixed, whole blood was me...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2001-02, Vol.21 (2), p.147-154
Main Authors: Koksch, M, Zeiger, F, Wittig, K, Siegemund, A, Reininger, C.B, Pfeiffer, D, Ruehlmann, C
Format: Article
Language:English
Subjects:
Blood Coagulation
Blood Platelets - metabolism
Coagulation
Female
Fibrinolysis
Flow cytometry
Humans
Male
P-selectin
P-Selectin - biosynthesis
Peripheral vascular disease
Peripheral Vascular Diseases - blood
Platelets
Prospective Studies
Sensitivity and Specificity
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Summary:Objectives: to examine coagulation, fibrinolysis, and platelet activity in patients with peripheral vascular disease (PVD). Design: fifty consecutive PVD patients and 50 healthy volunteers. (Prospective comparative study.) Materials and methods: P-selectin expression in non-fixed, whole blood was measured flow cytometrically on non-stimulated and ADP- and TRAP-6-stimulated samples. Plasma fibrinogen, von Willebrand factor (vWF), tissue plasÍminogen activator (tPA), and plasminogen activator inhibitor-1 were determined using standard techniques. Disease severity was stratified on the basis of the ankle-brachial pressure index (ABPI) and the angiographic data were assessed using the Bollinger score. Results: coagulation and fibrinolysis parameters as well as the P-selectin expression on both stimulated and non-stimulated platelets were significantly increased in patients vs controls (allp
ISSN:1078-5884
1532-2165
DOI:10.1053/ejvs.2000.1294