A multidimensional approach to analysis of cerebrospinal fluid biogenic amines in schizophrenia: I. Comparisons with healthy control subjects and neuroleptic-treated/ unmedicated pairs analyses

Recent hypotheses and findings indicate that measurements of interactions between cerebrospinal fluid (CSF) biogenic amine systems, rather than measurement of CSF biogenic amine metabolites, better correlate with clinically important findings in schizophrenia. To test these hypotheses, we used a rec...

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Bibliographic Details
Published in:Psychiatry research 1994-06, Vol.52 (3), p.237-249
Main Authors: Issa, Fuad, Gerhardt, Greg A., Bartko, John J., Suddath, Richard L., Lynch, Michael, Gamache, Paul H., Freedman, Robert, Wyatt, Richard Jed, Kirch, Darell G.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biogenic Amines - cerebrospinal fluid
Biological and medical sciences
Chromatography, High Pressure Liquid
Chronic Disease
coulometric electrochemical array system
Dopamine
Dopamine - cerebrospinal fluid
Double-Blind Method
Female
Haloperidol - therapeutic use
high performance liquid chromatography
Humans
kynurenine
Kynurenine - cerebrospinal fluid
Male
Medical sciences
norepinephrine
Norepinephrine - cerebrospinal fluid
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - cerebrospinal fluid
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Schizophrenic Psychology
serotonin
Serotonin - cerebrospinal fluid
Tryptophan - cerebrospinal fluid
Tyrosine - cerebrospinal fluid
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Summary:Recent hypotheses and findings indicate that measurements of interactions between cerebrospinal fluid (CSF) biogenic amine systems, rather than measurement of CSF biogenic amine metabolites, better correlate with clinically important findings in schizophrenia. To test these hypotheses, we used a recent technological advance in high performance liquid chromatography with electrochemical detection and combined it with multivariate statistical analyses to study biogenic amine concentrations in CSF in schizophrenia. This approach enabled the study of the interactions of several metabolites of each of the three major neurotransmitter pathways (dopaminergic, noradrenergic, and serotonergic) to test existing hypotheses regarding the neurobiochemical basis of schizophrenia. Twenty biogenic amines, their metabolites, and other compounds from 24 medication-free schizophrenic patients and 12 normal control subjects were simultaneously measured using a recently developed technique of gradient high performance liquid chromatography coupled with a 16-channel electrochemical array detector. After covariation for storage time, results of a stepwise discriminant function analysis comparing the control and patient groups identified tryptophan, tryptophol, and epinephrine as discriminating variables. Hotelling's paired T 2 test from a subgroup of schizophrenic patients studied while they were and were not receiving neuroleptic treatment did not yield any significant differences between subgroups. A discussion of the findings and a comparison with previous studies of CSF biogenic amines in schizophrenia are presented.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(94)90069-8