Mucosal and systemic humoral immune response to Bordetella avium in experimentally infected turkeys

Antibody response to Bordetella avium was measured in serum and mucosal secretions of experimentally infected turkeys. Two-day-old turkeys were inoculated with B. avium, and four inoculated turkeys and four uninoculated control birds per trial were euthanatized weekly from 1 through 8 weeks postinoc...

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Bibliographic Details
Published in:Avian diseases 1994-04, Vol.38 (2), p.225-230
Main Authors: Suresh, P, Arp, L.H, Huffman, E.L
Format: Article
Language:English
Subjects:
AGE
Aging - immunology
Animals
Antibodies
Antibody Formation
ANTICORPS
ANTICUERPOS
BORDETELLA
Bordetella - immunology
Bordetella avium
Bordetella Infections - immunology
DINDON
EDAD
EXPERIMENTACION IN VIVO
Experimentation
EXPERIMENTATION IN VIVO
Female
IMMUNITE HUMORALE
Immunoglobulin A - biosynthesis
Immunoglobulin A - blood
Immunoglobulin G - biosynthesis
Immunoglobulin G - blood
Immunoglobulin G - classification
Immunoglobulin M - biosynthesis
Immunoglobulin M - blood
IMMUNOGLOBULINE
INFECCION EXPERIMENTAL
INFECTION EXPERIMENTALE
Infections
INMUNIDAD HUMORAL
INMUNOGLOBULINA
Isotypes
Lacrimal Apparatus - immunology
LAGRIMA
LARME
Memory interference
Mucous Membrane - immunology
PAVO
Reference Values
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
SECRECION
SECRETION
SERUM SANGUIN
SUERO SANGUINEO
Trachea
Trachea - immunology
TRACHEE
TRAQUEA
Turkeys
Washing
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Summary:Antibody response to Bordetella avium was measured in serum and mucosal secretions of experimentally infected turkeys. Two-day-old turkeys were inoculated with B. avium, and four inoculated turkeys and four uninoculated control birds per trial were euthanatized weekly from 1 through 8 weeks postinoculation (PI). Maternal antibody of the IgG isotype, present in all 2-day-old birds sampled, decreased to background levels by 3 weeks of age. Antibody (IgG, IgM, IgA) was detected in serum, tracheal washings, and lacrimal secretions in response to B. avium infection. Regardless of the sample site and isotype, antibody levels peaked at 4-6 weeks PI and then decreased rapidly from 6 to 8 weeks PI. In general, IgM and IgA levels peaked earlier (4-5 weeks PI) but declined more rapidly than IgG levels. Numbers of B. avium in the trachea peaked at 2-3 weeks PI and then decreased rapidly from to 8 weeks PI. Even though no direct causal relationship could be determined, the results indicate that an increasing level of antibody in serum, tracheal washings, and lacrimal secretions is temporally associated with clearance of B. avium from the trachea
ISSN:0005-2086
1938-4351
DOI:10.2307/1591941