Placebo effect in double-blind clinical trials: a review of interactions with medications

A systematic evaluation of the evidence that the size of the specific effects of medications can be influenced by non-specific factors is presented. Placebo effects and the effects of informed-consent procedures are part of non-specific effects.

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Bibliographic Details
Published in:The Lancet (British edition) 1994-11, Vol.344 (8933), p.1347-1349
Main Authors: Kleijnen, J., de Craen, A.J.M., van Everdingen, J., Krol, L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Clinical trials
Double blind randomized trials
Double-Blind Method
General and cellular metabolism. Vitamins
Humans
Informed Consent
Medical sciences
Pharmacology
Pharmacology. Drug treatments
Placebo Effect
Placebos
Randomized Controlled Trials as Topic
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Description
Summary:A systematic evaluation of the evidence that the size of the specific effects of medications can be influenced by non-specific factors is presented. Placebo effects and the effects of informed-consent procedures are part of non-specific effects.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(94)90699-8