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Alectosarmentin, a New Antimicrobial Dibenzofuranoid Lactol from the Lichen, Alectoria sarmentosa
From the alcoholic extract of the lichen Alectoria sarmentosa, four compounds showing antimicrobial activity were isolated. Of these, (-)-usnic acid and physodic acid are well known lichen products, 8'-O-ethyl-beta-alectoronic acid [2] is believed to be an artifact formed during isolation and f...
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| Published in: | Journal of natural products (Washington, D.C.) D.C.), 1994-07, Vol.57 (7), p.934-938 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a404t-5b22864fa8667a8206c2acad99157432fa7e421743d792933cc538b811f493203 |
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| container_end_page | 938 |
| container_issue | 7 |
| container_start_page | 934 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 57 |
| creator | Gollapudi, Sitaraghav Rao Telikepalli, Hanumaiah Jampani, Hanuman B Mirhom, Youssef W Drake, Steven D Bhattiprolu, Kesava Rao Velde, David Vander Mitscher, Lester A |
| description | From the alcoholic extract of the lichen Alectoria sarmentosa, four compounds showing antimicrobial activity were isolated. Of these, (-)-usnic acid and physodic acid are well known lichen products, 8'-O-ethyl-beta-alectoronic acid [2] is believed to be an artifact formed during isolation and fractionation, and alectosarmentin [1] is a new natural product whose structure was shown, by spectroscopy and chemical transformations, to be that of a dibenzofuranoid lactol. The antimicrobial activity of these substances accounts for the activity of the lichen. |
| doi_str_mv | 10.1021/np50109a009 |
| format | article |
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Of these, (-)-usnic acid and physodic acid are well known lichen products, 8'-O-ethyl-beta-alectoronic acid [2] is believed to be an artifact formed during isolation and fractionation, and alectosarmentin [1] is a new natural product whose structure was shown, by spectroscopy and chemical transformations, to be that of a dibenzofuranoid lactol. 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Nat. Prod</addtitle><description>From the alcoholic extract of the lichen Alectoria sarmentosa, four compounds showing antimicrobial activity were isolated. Of these, (-)-usnic acid and physodic acid are well known lichen products, 8'-O-ethyl-beta-alectoronic acid [2] is believed to be an artifact formed during isolation and fractionation, and alectosarmentin [1] is a new natural product whose structure was shown, by spectroscopy and chemical transformations, to be that of a dibenzofuranoid lactol. 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Telikepalli, Hanumaiah ; Jampani, Hanuman B ; Mirhom, Youssef W ; Drake, Steven D ; Bhattiprolu, Kesava Rao ; Velde, David Vander ; Mitscher, Lester A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a404t-5b22864fa8667a8206c2acad99157432fa7e421743d792933cc538b811f493203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Alectoria sarmentosa</topic><topic>Anti-Bacterial Agents</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - isolation & purification</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>ANTIMICROBIAL PROPERTIES</topic><topic>Bacteria - drug effects</topic><topic>Benzofurans - chemistry</topic><topic>Benzofurans - isolation & purification</topic><topic>Benzofurans - pharmacology</topic><topic>Candida - drug effects</topic><topic>CHEMICAL COMPOSITION</topic><topic>COMPOSICION QUIMICA</topic><topic>COMPOSITION CHIMIQUE</topic><topic>DERIVATIVES</topic><topic>FURANNE</topic><topic>FURANOS</topic><topic>FURANS</topic><topic>LICHEN</topic><topic>LICHENES</topic><topic>Lichens - chemistry</topic><topic>LIQUENES</topic><topic>Microbial Sensitivity Tests</topic><topic>MOLECULAR CONFORMATION</topic><topic>MOLECULAR STRUCTURE</topic><topic>PROPIEDADES ANTIMICROBIANAS</topic><topic>PROPRIETE ANTIMICROBIENNE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gollapudi, Sitaraghav Rao</creatorcontrib><creatorcontrib>Telikepalli, Hanumaiah</creatorcontrib><creatorcontrib>Jampani, Hanuman B</creatorcontrib><creatorcontrib>Mirhom, Youssef W</creatorcontrib><creatorcontrib>Drake, Steven D</creatorcontrib><creatorcontrib>Bhattiprolu, Kesava Rao</creatorcontrib><creatorcontrib>Velde, David Vander</creatorcontrib><creatorcontrib>Mitscher, Lester A</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gollapudi, Sitaraghav Rao</au><au>Telikepalli, Hanumaiah</au><au>Jampani, Hanuman B</au><au>Mirhom, Youssef W</au><au>Drake, Steven D</au><au>Bhattiprolu, Kesava Rao</au><au>Velde, David Vander</au><au>Mitscher, Lester A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alectosarmentin, a New Antimicrobial Dibenzofuranoid Lactol from the Lichen, Alectoria sarmentosa</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>57</volume><issue>7</issue><spage>934</spage><epage>938</epage><pages>934-938</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><notes>9515828</notes><notes>F60</notes><notes>istex:D816A89EF97AEDA9BED12685D7A83D672B77E974</notes><notes>ark:/67375/TPS-L9TX4VLG-4</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>From the alcoholic extract of the lichen Alectoria sarmentosa, four compounds showing antimicrobial activity were isolated. Of these, (-)-usnic acid and physodic acid are well known lichen products, 8'-O-ethyl-beta-alectoronic acid [2] is believed to be an artifact formed during isolation and fractionation, and alectosarmentin [1] is a new natural product whose structure was shown, by spectroscopy and chemical transformations, to be that of a dibenzofuranoid lactol. The antimicrobial activity of these substances accounts for the activity of the lichen.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>7964789</pmid><doi>10.1021/np50109a009</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1994-07, Vol.57 (7), p.934-938 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76826373 |
| source | ACS CRKN Legacy Archives |
| subjects | Alectoria sarmentosa Anti-Bacterial Agents Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology ANTIMICROBIAL PROPERTIES Bacteria - drug effects Benzofurans - chemistry Benzofurans - isolation & purification Benzofurans - pharmacology Candida - drug effects CHEMICAL COMPOSITION COMPOSICION QUIMICA COMPOSITION CHIMIQUE DERIVATIVES FURANNE FURANOS FURANS LICHEN LICHENES Lichens - chemistry LIQUENES Microbial Sensitivity Tests MOLECULAR CONFORMATION MOLECULAR STRUCTURE PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE |
| title | Alectosarmentin, a New Antimicrobial Dibenzofuranoid Lactol from the Lichen, Alectoria sarmentosa |
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