Alectosarmentin, a New Antimicrobial Dibenzofuranoid Lactol from the Lichen, Alectoria sarmentosa

From the alcoholic extract of the lichen Alectoria sarmentosa, four compounds showing antimicrobial activity were isolated. Of these, (-)-usnic acid and physodic acid are well known lichen products, 8'-O-ethyl-beta-alectoronic acid [2] is believed to be an artifact formed during isolation and f...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1994-07, Vol.57 (7), p.934-938
Main Authors: Gollapudi, Sitaraghav Rao, Telikepalli, Hanumaiah, Jampani, Hanuman B, Mirhom, Youssef W, Drake, Steven D, Bhattiprolu, Kesava Rao, Velde, David Vander, Mitscher, Lester A
Format: Article
Language:English
Subjects:
Alectoria sarmentosa
Anti-Bacterial Agents
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
ANTIMICROBIAL PROPERTIES
Bacteria - drug effects
Benzofurans - chemistry
Benzofurans - isolation & purification
Benzofurans - pharmacology
Candida - drug effects
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
DERIVATIVES
FURANNE
FURANOS
FURANS
LICHEN
LICHENES
Lichens - chemistry
LIQUENES
Microbial Sensitivity Tests
MOLECULAR CONFORMATION
MOLECULAR STRUCTURE
PROPIEDADES ANTIMICROBIANAS
PROPRIETE ANTIMICROBIENNE
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:From the alcoholic extract of the lichen Alectoria sarmentosa, four compounds showing antimicrobial activity were isolated. Of these, (-)-usnic acid and physodic acid are well known lichen products, 8'-O-ethyl-beta-alectoronic acid [2] is believed to be an artifact formed during isolation and fractionation, and alectosarmentin [1] is a new natural product whose structure was shown, by spectroscopy and chemical transformations, to be that of a dibenzofuranoid lactol. The antimicrobial activity of these substances accounts for the activity of the lichen.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50109a009