Galactose consumption, metabolism, and follicle-stimulating hormone concentrations in women of late reproductive age

To test the hypothesis that high galactose consumption and low activity of galactose-1-phosphate uridyl transferase (transferase) is associated with early ovarian senescence among nongalactosemic women. Cross-sectional study. Data collection consisted of a self-administered questionnaire with sectio...

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Bibliographic Details
Published in:Fertility and sterility 1994-12, Vol.62 (6), p.1168-1175
Main Authors: Cooper, Glinda S., Hulka, Barbara S., Baird, Donna D., Savitz, David A., Hughes, Claude L., Weinberg, Clarice R., Coleman, Rosalind A., Shields, Joan M.
Format: Article
Language:English
Subjects:
Adult
Aging - metabolism
Biological and medical sciences
Cross-Sectional Studies
Diet
Estrogen Replacement Therapy
Female
Female genital diseases
Follicle Stimulating Hormone - blood
follicle-stimulating hormone
Galactose - administration & dosage
Galactose - metabolism
Galactose - pharmacology
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
menopausal status
Menopause
Menstrual Cycle
Middle Aged
Non tumoral diseases
Osmolar Concentration
ovarian toxicity
Transferases - blood
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Summary:To test the hypothesis that high galactose consumption and low activity of galactose-1-phosphate uridyl transferase (transferase) is associated with early ovarian senescence among nongalactosemic women. Cross-sectional study. Data collection consisted of a self-administered questionnaire with sections on diet (food frequency data to measure galactose consumption), reproductive, and medical histories. One blood sample was collected to measure FSH and transferase activity; FSH was used as a measure of ovarian senescence. Among women who were having menstrual periods at least every 8weeks, the blood sample was drawn in the early follicular phase (days 2 to 4) of a menstrual cycle. Two hundred ninety-five women volunteers ages 38 to 49years who had not had a hysterectomy or oophorectomy were recruited through posters and advertisements. Serum FSH concentrations. Controlling for age, smoking, and body mass, transferase activity and FSH were unrelated. However, FSH levels were 29% higher (95% confidence intervals, 9% to 52%) among women who reported consuming ≥6g galactose/d. These data do not support the hypothesis that low transferase activity represents a genetic predisposition for early ovarian senescence, as measured by FSH levels in women ages 38 to 49years. However, the hypothesized positive association between galactose consumption and FSH was supported.
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(16)57180-5