Controlled Trial of Desmopressin in Liver Cirrhosis and Other Conditions Associated With a Prolonged Bleeding Time

The synthetic vasopressin derivative desmopressin (DDAVP) shortens a prolonged bleeding time (BT) in patients with uremia, congenital platelet dysfunction, and von Willebrand disease. To establish the limits of the clinical usefulness of DDAVP, a controlled randomized study was carried out in 53 pat...

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Bibliographic Details
Published in:Blood 1986-04, Vol.67 (4), p.1148-1153
Main Authors: Mannucci, Pier Mannuccio, Vicente, Vicente, Vianello, Luciana, Cattaneo, Marco, Alberca, Ignacio, Coccato, Maria Piera, Faioni, Elena, Mari, Daniela
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aspirin - pharmacology
Biological and medical sciences
Bleeding Time
Blood. Blood coagulation. Reticuloendothelial system
Clinical Trials as Topic
Deamino Arginine Vasopressin - therapeutic use
Female
Humans
Liver Cirrhosis - blood
Liver Cirrhosis - drug therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Platelet Count
Platelet Function Tests
Random Allocation
Thiophenes - pharmacology
Thrombocytopenia - blood
Ticlopidine
von Willebrand Factor - analysis
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Summary:The synthetic vasopressin derivative desmopressin (DDAVP) shortens a prolonged bleeding time (BT) in patients with uremia, congenital platelet dysfunction, and von Willebrand disease. To establish the limits of the clinical usefulness of DDAVP, a controlled randomized study was carried out in 53 patients and ten volunteers with different conditions that have in common a prolonged BT. DDAVP significantly shortened the BT in 21 cirrhotics (P
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V67.4.1148.1148