Myocardial Involvement in Patients With Sarcoidosis: An Analysis of 75 Patients

The authors studied 75 nonselected patients (30 men and 45 women; mean age 48 years) with sarcoidosis retrospectively to assess the applicability of nuclear examinations for detecting myocardial involvement. All patients were studied with TI-201 myocardial perfusion scan (TMPS), Ga-67 myocardial sca...

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Bibliographic Details
Published in:Clinical nuclear medicine 1994-06, Vol.19 (6), p.522-526
Main Authors: HIROSE, YOSHIAKI, ISHIDA, YOSHIO, HAYASHIDA, KOHEI, MAENO, MASAKAZU, TAKAMIYA, MAKOTO, OHMORI, FUMIO, MIYATAKE, KUNIO, UEHARA, TOSHIISA, NISHIMURA, TSUNEHIKO, TACHIBANA, TERUO
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiomyopathies - diagnostic imaging
Cardiomyopathies - physiopathology
Electrocardiography
Female
Gallium Radioisotopes
Heart - diagnostic imaging
Humans
Male
Medical sciences
Middle Aged
Radionuclide Ventriculography
Sarcoidosis - diagnostic imaging
Sarcoidosis - physiopathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Stroke Volume - physiology
Thallium Radioisotopes
Ventricular Function, Left - physiology
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Summary:The authors studied 75 nonselected patients (30 men and 45 women; mean age 48 years) with sarcoidosis retrospectively to assess the applicability of nuclear examinations for detecting myocardial involvement. All patients were studied with TI-201 myocardial perfusion scan (TMPS), Ga-67 myocardial scan (GMS), and left ventricular ejection fraction (LVEF) using ECG-gated radionuclide ventriculography. The positive GMS group had a significantly higher occurrence of abnormality on TMPS (100%) than the negative GMS group (41%). Patients with TMPS abnormality and positive GMS showed significantly lower LVEF (36.3%) than those of normal perfusion or negative GMS. When LVEF decreased, occurrences of TMPS abnormality and positive GMS increased. The authors demonstrate that in patients with sarcoidosis LVEF was closely related to TMPS and GMS, and LVEF reflected the progression of sarcoid heart disease and can be considered a reliable indicator of cardiac function. Patients with sarcoidosis with TMPS abnormality and positive GMS should be thought to have myocardial sarcoidosis and their cardiac functions can be assessed by ECG-gated radionuclide ventriculography, while the remaining patients should be examined with TMPS and GMS periodically for detection of myocardial involvement.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199406000-00012