Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor

13 women admitted consecutively in preterm labour were recruited to an observational study of the effect of glyceryl trinitrate (GTN) patches on uterine contractions and prolongation of pregnancy. All twenty episodes of preterm labour (at 23-33 weeks' gestation) responded. 1 patient delivered b...

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Bibliographic Details
Published in:	The Lancet (British edition) 1994-05, Vol.343 (8909), p.1325-1326
Main Authors:	Lees, C., Campbell, S., Jauniaux, E., Brown, R., Ramsay, B., Gibb, D., Martin, J.F., Moncada, S.
Format:	Article
Language:	eng
Subjects:	Administration, Cutaneous Biological and medical sciences Female Genital system. Reproduction Health care Humans Medical research Medical sciences Nitroglycerin - pharmacology Nitroglycerin - therapeutic use Obstetric Labor, Premature - drug therapy Pharmacology. Drug treatments Pregnancy Premature labor Uterine Contraction - drug effects
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Summary:	13 women admitted consecutively in preterm labour were recruited to an observational study of the effect of glyceryl trinitrate (GTN) patches on uterine contractions and prolongation of pregnancy. All twenty episodes of preterm labour (at 23-33 weeks' gestation) responded. 1 patient delivered because of cervical incompetence despite cessation of uterine contractions. The mean prolongation of pregnancy was 34 days. 8 babies have been born so far, and are progressing well. GTN patches appear to be a safe, well-tolerated, and non-invasive method of suppressing uterine contractions in preterm labour.
ISSN:	0140-6736 1474-547X