Application and Accuracy of Molecular Phylogenies

Molecular investigations of evolutionary history are being used to study subjects as diverse as the epidemiology of acquired immune deficiency syndrome and the origin of life. These studies depend on accurate estimates of phylogeny. The performance of methods of phylogenetic analysis can be assessed...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1994-04, Vol.264 (5159), p.671-677
Main Authors: Hillis, David M., Huelsenbeck, John P., Cunningham, Clifford W.
Format: Article
Language:English
Subjects:
Accuracy
Acquired immune deficiency syndrome
AIDS
AIDS/HIV
Algorithms
Bacteriophage T7 - genetics
Biological and medical sciences
Biological Evolution
Cell death
Computer Simulation
Dentists
Evolution
Evolution (Biology)
Female
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Genome, Viral
HIV
HIV (Viruses)
HIV - genetics
HIV Envelope Protein gp120 - genetics
HIV Infections - microbiology
HIV Infections - transmission
Humans
Infectious Disease Transmission, Professional-to-Patient
Male
Modeling
Models, Biological
Nucleotides
Parsimony
Personality
Phylogenetics
Phylogeny
Probability
Simulations
Term weighting
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Summary:Molecular investigations of evolutionary history are being used to study subjects as diverse as the epidemiology of acquired immune deficiency syndrome and the origin of life. These studies depend on accurate estimates of phylogeny. The performance of methods of phylogenetic analysis can be assessed by numerical simulation studies and by the experimental evolution of organisms in controlled laboratory situations. Both kinds of assessment indicate that existing methods are effective at estimating phylogenies over a wide range of evolutionary conditions, especially if information about substitution bias is used to provide differential weightings for character transformations.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8171318