Gamma camera evaluation of the effects of degradable starch microspheres on arterial liver blood flow in the rat

Degradable starch microspheres injected into an artery causes a temporary reduction of regional blood flow and improves the exposure of the organ to a drug injected simultaneously. The purpose of this study was to quantify this effect when microspheres are injected arterially into the liver of rats....

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Bibliographic Details
Published in:Research in experimental medicine 1985-01, Vol.185 (5), p.391-397
Main Authors: TEDER, H, NILSSON, M, ARONSEN, K.-F
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Arteries - diagnostic imaging
Arteries - physiology
Biological and medical sciences
General aspects
Liver - diagnostic imaging
Liver Circulation
Male
Medical sciences
Microspheres
Pharmacology. Drug treatments
Radionuclide Imaging
Rats
Rats, Inbred Strains
Sodium Pertechnetate Tc 99m
Starch - pharmacology
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Summary:Degradable starch microspheres injected into an artery causes a temporary reduction of regional blood flow and improves the exposure of the organ to a drug injected simultaneously. The purpose of this study was to quantify this effect when microspheres are injected arterially into the liver of rats. As model substance radioactive pertechnetate ions (99TcmO4-) was used. The results were evaluated from external gamma camera measurements. The amounts of microspheres injected together with pertechnetate was 1.5-12 mg. When compared to injections of pertechnetate only, the integrated exposure of the liver to pertechnetate was increased by a factor of 1.4-2.4 when microspheres were added.
ISSN:0300-9130
1433-8580
DOI:10.1007/BF01851919