Cell instability in basophil leukocytes of patients with chronic obstructive airway disease

The histamine release from basophils induced by hypo-osmolarity was investigated in 75 healthy persons and in 43 patients with chronic obstructive airway disease. Leukocyte suspensions were diluted with destilled water in cell/water ratio volumen of 1:1, 1:3, and 1:7. Basophils, sequentially treated...

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Bibliographic Details
Published in:Research in experimental medicine 1985-01, Vol.185 (5), p.415-423
Main Authors: HEERING, P, ZIMMERMANN, I, BUGALHO DE ALMEIDA, A. A, ULMER, W. T
Format: Article
Language:English
Subjects:
Adult
Age Factors
Basophils - cytology
Basophils - immunology
Biological and medical sciences
Bronchitis - immunology
Chronic obstructive pulmonary disease, asthma
Female
Histamine Release
Humans
Lung Diseases, Obstructive - immunology
Male
Medical sciences
Middle Aged
Pneumology
Reference Values
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Summary:The histamine release from basophils induced by hypo-osmolarity was investigated in 75 healthy persons and in 43 patients with chronic obstructive airway disease. Leukocyte suspensions were diluted with destilled water in cell/water ratio volumen of 1:1, 1:3, and 1:7. Basophils, sequentially treated with increasing amounts of water, show an activation of the release process. A statistically significant age-dependent hypo-osmolar histamine liberation could be demonstrated. Furthermore, a significant higher cell stability was found for the group of patients.
ISSN:0300-9130
1433-8580
DOI:10.1007/BF01851922