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Community-associated meticillin-resistant Staphylococcus aureus : epidemiology, microbiology and clinical impact in East Yorkshire, UK
Summary The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing worldwide. Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yor...
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| Published in: | The Journal of hospital infection 2009-08, Vol.72 (4), p.307-313 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c502t-db874aee2093431d2691e94df2a15b21b46a04518634b0fa8582e2a9894699ed3 |
| container_end_page | 313 |
| container_issue | 4 |
| container_start_page | 307 |
| container_title | The Journal of hospital infection |
| container_volume | 72 |
| creator | Elston, J.W.T Meigh, J Kearns, A.M Jordan-Owers, N Newton, A Meigh, R.E Barlow, G |
| description | Summary The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing worldwide. Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yorkshire and describe their epidemiology, microbiology and clinical impact. Although CA-MRSA was most often associated with uncomplicated skin and soft tissue infections or asymptomatic colonisation, serious infection and fatalities were documented. Community-based transmission was noted in two separate households. We highlight limitations to existing definitions and propose debate to further define CA-MRSA and allow further study of its epidemiology and clinical impact in the UK. |
| doi_str_mv | 10.1016/j.jhin.2009.05.001 |
| format | article |
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Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yorkshire and describe their epidemiology, microbiology and clinical impact. Although CA-MRSA was most often associated with uncomplicated skin and soft tissue infections or asymptomatic colonisation, serious infection and fatalities were documented. Community-based transmission was noted in two separate households. We highlight limitations to existing definitions and propose debate to further define CA-MRSA and allow further study of its epidemiology and clinical impact in the UK.</description><identifier>ISSN: 0195-6701</identifier><identifier>EISSN: 1532-2939</identifier><identifier>DOI: 10.1016/j.jhin.2009.05.001</identifier><identifier>PMID: 19596493</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Bacterial Typing Techniques - methods ; Biological and medical sciences ; Child ; Child, Preschool ; Clinical impact ; Cluster Analysis ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - microbiology ; Community-associated ; DNA Fingerprinting - methods ; DNA, Bacterial - genetics ; Electrophoresis, Gel, Pulsed-Field - methods ; Epidemiology ; Female ; Genotype ; Human bacterial diseases ; Humans ; Infant ; Infant, Newborn ; Infectious Disease ; Infectious diseases ; Male ; Medical sciences ; Methicillin-Resistant Staphylococcus aureus - classification ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Meticillin-resistant Staphylococcus aureus ; Middle Aged ; Molecular Epidemiology ; Panton–Valentine leucocidin ; Pharmacology. 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Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yorkshire and describe their epidemiology, microbiology and clinical impact. Although CA-MRSA was most often associated with uncomplicated skin and soft tissue infections or asymptomatic colonisation, serious infection and fatalities were documented. Community-based transmission was noted in two separate households. We highlight limitations to existing definitions and propose debate to further define CA-MRSA and allow further study of its epidemiology and clinical impact in the UK.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial diseases</subject><subject>Bacterial Typing Techniques - methods</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical impact</subject><subject>Cluster Analysis</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Community-associated</subject><subject>DNA Fingerprinting - methods</subject><subject>DNA, Bacterial - genetics</subject><subject>Electrophoresis, Gel, Pulsed-Field - methods</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methicillin-Resistant Staphylococcus aureus - classification</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Methicillin-Resistant Staphylococcus aureus - isolation & purification</subject><subject>Meticillin-resistant Staphylococcus aureus</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Panton–Valentine leucocidin</subject><subject>Pharmacology. Drug treatments</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus</subject><subject>United Kingdom - epidemiology</subject><subject>Young Adult</subject><issn>0195-6701</issn><issn>1532-2939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFks9u1DAQhyMEokvhBTggX4BLE2wnduIKIVWr8kdU4lB64GQ5zoT1NrGD7VTKC_DcONoFJA7lZNn6fqPxfJNlzwkuCCb8zb7Y74wtKMaiwKzAmDzINoSVNKeiFA-zDSaC5bzG5CR7EsIeJ7AU7HF2kt4Fr0S5yX5u3TjO1sQlVyE4bVSEDo0QjTbDYGzuIZgQlY3oOqpptwxOO63ngNTsIR3nCCbTwWjc4L4vZ2g02rv2cEPKdkinKkarAZlxUjoiY9GlChF9c_427IyHM3Tz-Wn2qFdDgGfH8zS7eX_5dfsxv_ry4dP24irXDNOYd21TVwqApo9UJekoFwRE1fVUEdZS0lZc4YqRhpdVi3vVsIYCVaIRFRcCuvI0e32oO3n3Y4YQ5WiChmFQFtwcZM2rUlDe1Il8dS_Ja0brUlT_BSmmlFDOEkgPYBpQCB56OXkzKr9IguUqVO7lKlSuQiVmMglNoRfH6nM7Qvc3cjSYgJdHQIU05d4rq034w1HS1A1ja5tvDxyk8d4Z8DJoA1ZDlxToKDtn7u_j3T_x315vYYGwd7O3SZwkMlCJ5fW6euvmYZHSTerzF0yM1NE</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Elston, J.W.T</creator><creator>Meigh, J</creator><creator>Kearns, A.M</creator><creator>Jordan-Owers, N</creator><creator>Newton, A</creator><creator>Meigh, R.E</creator><creator>Barlow, G</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope></search><sort><creationdate>20090801</creationdate><title>Community-associated meticillin-resistant Staphylococcus aureus : epidemiology, microbiology and clinical impact in East Yorkshire, UK</title><author>Elston, J.W.T ; Meigh, J ; Kearns, A.M ; Jordan-Owers, N ; Newton, A ; Meigh, R.E ; Barlow, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-db874aee2093431d2691e94df2a15b21b46a04518634b0fa8582e2a9894699ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial diseases</topic><topic>Bacterial Typing Techniques - methods</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical impact</topic><topic>Cluster Analysis</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Community-Acquired Infections - microbiology</topic><topic>Community-associated</topic><topic>DNA Fingerprinting - methods</topic><topic>DNA, Bacterial - genetics</topic><topic>Electrophoresis, Gel, Pulsed-Field - methods</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genotype</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methicillin-Resistant Staphylococcus aureus - classification</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Methicillin-Resistant Staphylococcus aureus - isolation & purification</topic><topic>Meticillin-resistant Staphylococcus aureus</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Panton–Valentine leucocidin</topic><topic>Pharmacology. Drug treatments</topic><topic>Staphylococcal Infections - epidemiology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Staphylococcus aureus</topic><topic>United Kingdom - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elston, J.W.T</creatorcontrib><creatorcontrib>Meigh, J</creatorcontrib><creatorcontrib>Kearns, A.M</creatorcontrib><creatorcontrib>Jordan-Owers, N</creatorcontrib><creatorcontrib>Newton, A</creatorcontrib><creatorcontrib>Meigh, R.E</creatorcontrib><creatorcontrib>Barlow, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>The Journal of hospital infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elston, J.W.T</au><au>Meigh, J</au><au>Kearns, A.M</au><au>Jordan-Owers, N</au><au>Newton, A</au><au>Meigh, R.E</au><au>Barlow, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Community-associated meticillin-resistant Staphylococcus aureus : epidemiology, microbiology and clinical impact in East Yorkshire, UK</atitle><jtitle>The Journal of hospital infection</jtitle><addtitle>J Hosp Infect</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>72</volume><issue>4</issue><spage>307</spage><epage>313</epage><pages>307-313</pages><issn>0195-6701</issn><eissn>1532-2939</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Summary The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing worldwide. Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yorkshire and describe their epidemiology, microbiology and clinical impact. Although CA-MRSA was most often associated with uncomplicated skin and soft tissue infections or asymptomatic colonisation, serious infection and fatalities were documented. Community-based transmission was noted in two separate households. We highlight limitations to existing definitions and propose debate to further define CA-MRSA and allow further study of its epidemiology and clinical impact in the UK.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19596493</pmid><doi>10.1016/j.jhin.2009.05.001</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0195-6701 |
| ispartof | The Journal of hospital infection, 2009-08, Vol.72 (4), p.307-313 |
| issn | 0195-6701 1532-2939 |
| language | eng |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Bacterial Typing Techniques - methods Biological and medical sciences Child Child, Preschool Clinical impact Cluster Analysis Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Community-associated DNA Fingerprinting - methods DNA, Bacterial - genetics Electrophoresis, Gel, Pulsed-Field - methods Epidemiology Female Genotype Human bacterial diseases Humans Infant Infant, Newborn Infectious Disease Infectious diseases Male Medical sciences Methicillin-Resistant Staphylococcus aureus - classification Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Meticillin-resistant Staphylococcus aureus Middle Aged Molecular Epidemiology Panton–Valentine leucocidin Pharmacology. Drug treatments Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus United Kingdom - epidemiology Young Adult |
| title | Community-associated meticillin-resistant Staphylococcus aureus : epidemiology, microbiology and clinical impact in East Yorkshire, UK |
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