Community-associated meticillin-resistant Staphylococcus aureus : epidemiology, microbiology and clinical impact in East Yorkshire, UK

Summary The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing worldwide. Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yor...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of hospital infection 2009-08, Vol.72 (4), p.307-313
Main Authors: Elston, J.W.T, Meigh, J, Kearns, A.M, Jordan-Owers, N, Newton, A, Meigh, R.E, Barlow, G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Bacterial Typing Techniques - methods
Biological and medical sciences
Child
Child, Preschool
Clinical impact
Cluster Analysis
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Community-associated
DNA Fingerprinting - methods
DNA, Bacterial - genetics
Electrophoresis, Gel, Pulsed-Field - methods
Epidemiology
Female
Genotype
Human bacterial diseases
Humans
Infant
Infant, Newborn
Infectious Disease
Infectious diseases
Male
Medical sciences
Methicillin-Resistant Staphylococcus aureus - classification
Methicillin-Resistant Staphylococcus aureus - genetics
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Meticillin-resistant Staphylococcus aureus
Middle Aged
Molecular Epidemiology
Panton–Valentine leucocidin
Pharmacology. Drug treatments
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
United Kingdom - epidemiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing worldwide. Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yorkshire and describe their epidemiology, microbiology and clinical impact. Although CA-MRSA was most often associated with uncomplicated skin and soft tissue infections or asymptomatic colonisation, serious infection and fatalities were documented. Community-based transmission was noted in two separate households. We highlight limitations to existing definitions and propose debate to further define CA-MRSA and allow further study of its epidemiology and clinical impact in the UK.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2009.05.001