Three CA/GT repeat polymorphisms from loci D21S414 and D21S1234 on human chromosome 21

We report three new polymorphic CA repeat microsatellites (ABM-21, ABM-C37A, and ABM-C37B) in two different loci (D21S414 and D21S1234), located in bands q21 and q11.2 of human chromosome 21 (HC21) and that were isolated from a HC21 phage library (LA21NS01). Heterozygosities for ABM-21, ABM-C37A, an...

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Bibliographic Details
Published in:	Human genetics 1994-03, Vol.93 (3), p.359-360
Main Authors:	BOSCH, A, WIEMANN, S, ANSORGE, W, PATTERSON, D, ESTIVILL, X
Format:	Article
Language:	eng
Subjects:	Base Sequence Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 21 Classical genetics, quantitative genetics, hybrids DNA Primers DNA, Satellite Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Heterozygote Human Humans Male Molecular Sequence Data Pedigree Polymerase Chain Reaction Polymorphism, Genetic Repetitive Sequences, Nucleic Acid
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Summary:	We report three new polymorphic CA repeat microsatellites (ABM-21, ABM-C37A, and ABM-C37B) in two different loci (D21S414 and D21S1234), located in bands q21 and q11.2 of human chromosome 21 (HC21) and that were isolated from a HC21 phage library (LA21NS01). Heterozygosities for ABM-21, ABM-C37A, and ABM-C37B were 0.74, 0.50, and 0.67 respectively. These three CA repeat markers should be useful in the construction of a high resolution genetic map of this region of HC21.
ISSN:	0340-6717 1432-1203