Differential Expression of Proinflammatory Cytokines and Their Inhibitors during the Course of Meningococcal Infections

Circulating concentrations of tumor necrosis factor-α (TNF), interleukin (IL)-1β, IL-6, IL-1 receptor antagonist (IL-1ra), and soluble TNF receptors p55 (sTNFr-55) and p75 (sTNFr-75) and ex vivo production ofTNF, IL-1, IL-6, and IL-1ra using a whole blood culture system were measured during the acut...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-01, Vol.169 (1), p.157-161
Main Authors: van Deuren, Marcel, van der Ven Jongekrijg, Johanna, Demacker, Pierre N. M., Bartelink, Anton K. M., van Dalen, Roelof, Sauerwein, Robert W., Gallati, Harald, Vannice, James L., van der Meer, Jos W. M.
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Blood
Blood plasma
Child, Preschool
Cytokines
Cytokines - biosynthesis
Endotoxins
Endotoxins - blood
Female
Gene Expression Regulation
Hemorrhagic fever with renal syndrome
Human bacterial diseases
Humans
Infectious diseases
Interleukin 1 Receptor Antagonist Protein
Interleukin-1 - biosynthesis
Interleukin-6 - biosynthesis
Interleukins
Lipopolysaccharides - immunology
Major Articles
Male
Medical sciences
Meningococcal infections
Meningococcal Infections - immunology
Neisseria meningitidis
Radioimmunoassay
Receptors
Receptors, Tumor Necrosis Factor - biosynthesis
Sialoglycoproteins - blood
Time Factors
Tumor Necrosis Factor-alpha - biosynthesis
Tumor necrosis factors
Viruses
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Summary:Circulating concentrations of tumor necrosis factor-α (TNF), interleukin (IL)-1β, IL-6, IL-1 receptor antagonist (IL-1ra), and soluble TNF receptors p55 (sTNFr-55) and p75 (sTNFr-75) and ex vivo production ofTNF, IL-1, IL-6, and IL-1ra using a whole blood culture system were measured during the acute and convalescent stages of meningococcal infection. Circulating TNF and IL-1 were below detection level, whereas IL-6 and IL-1ra, sTNFr-55, and sTNFr-75 were increased at admission. The ex vivo production of proinflammatory cytokines TNF, IL-1, and IL-6 was suppressed at admission and restored gradually during recovery. On the contrary, the production of the antiinflammatory IL-1ra was increased at admission. The elevated concentrations of both IL-1ra and sTNFr early in the course of infection suggest a regulatory role for these antiinflammatory compounds. The observed down-regulation of the ex vivo production of TNF, IL-1, and IL-6 and up-regulation of the production of IL-1 ra in the acute stage may indicate a protective regulation mechanism.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/169.1.157