Carotid atherosclerosis in familial hypercholesterolemia

Common and internal carotids have been studied by noninvasive method (echo-Doppler) in 30 normotensive patients with familial hypercholesterolemia (FH). Vascular lesions were detected in 14 patients (46%), who presented one or more lesions of different degree (between 1-15% and 16-49%). In one case,...

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Bibliographic Details
Published in:Stroke (1970) 1985-07, Vol.16 (4), p.658-661
Main Authors: POSTIGLIONE, A, RUBBA, P, DE SIMONE, B, PATTI, L, CICERANO, U, MANCINI, M
Format: Article
Language:English
Subjects:
Apolipoproteins - blood
Arteriosclerosis - diagnosis
Arteriosclerosis - etiology
Biological and medical sciences
Carotid Artery Diseases - diagnosis
Carotid Artery Diseases - etiology
Cholesterol, LDL - blood
Disorders of blood lipids. Hyperlipoproteinemia
Female
Humans
Hyperlipoproteinemia Type II - complications
Male
Medical sciences
Metabolic diseases
Ultrasonography
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Summary:Common and internal carotids have been studied by noninvasive method (echo-Doppler) in 30 normotensive patients with familial hypercholesterolemia (FH). Vascular lesions were detected in 14 patients (46%), who presented one or more lesions of different degree (between 1-15% and 16-49%). In one case, only one carotid had stenosis greater than 50%. Severity and number of stenosis were related to age and levels of hypercholesterolemia. FH patients with carotid lesions showed a significantly higher LDL-cholesterol (p less than 0.01) and plasma apolipoprotein B (p less than 0.001) concentrations and a significantly lower HDL-cholesterol (p less than 0.05) and plasma apolipoprotein A (p less than 0.001) levels as compared to those with normal echo-Doppler findings. These data indicate that investigation of arterial districts other than coronaries are useful in quantitative evaluation of atherosclerotic involvement.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.16.4.658