Sequence Homology between Certain Viral Proteins and Proteins Related to Encephalomyelitis and Neuritis

Post-infectious or post-vaccinal demyelinating encephalomyelitis and neuritis may be due to immunological cross-reactions evoked by specific viral antigenic determinants (epitopes) that are homologous to regions in the target myelins of the central and peripheral nervous systems. Such homologies hav...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1985-07, Vol.229 (4710), p.282-284
Main Authors: Jahnke, Ulrike, Fischer, Edmond H., Alvord, Ellsworth C.
Format: Article
Language:English
Subjects:
Adenoviruses
amino acid sequence
Amino acids
Animals
Base Sequence
Biochemistry
Biological and medical sciences
Chickens
Encephalomyelitis
Encephalomyelitis - etiology
Encephalomyelitis - immunology
Encephalomyelitis - metabolism
Epitopes
Epstein-Barr virus
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Haplorhini
Humans
Influenza A virus
Measles
Measles - metabolism
measles virus
Microbiology
Myelin
Myelin Basic Protein - genetics
Myelin P2 Protein
Nerves
Neuritis
Neuritis - etiology
Neuritis - immunology
Neuritis - metabolism
Pathology
proteins
Rabbits
Rats
Rats, Inbred Lew
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Viral proteins
Viral Proteins - genetics
Viral Vaccines - adverse effects
Viral Vaccines - immunology
Virology
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Post-infectious or post-vaccinal demyelinating encephalomyelitis and neuritis may be due to immunological cross-reactions evoked by specific viral antigenic determinants (epitopes) that are homologous to regions in the target myelins of the central and peripheral nervous systems. Such homologies have been found by computer searches in which decapeptides in two human myelin proteins were compared with proteins of viruses known to infect humans. These viruses include measles, Epstein-Barr, influenza A and B, and others that cause upper respiratory infections. Several regions identified in myelin basic protein and P$_{2}$ protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2409602