Further Lupane Lactones from Kokoona ochracea

Additional new lupane lactones were isolated from the stem bark of Kokoona ochracea (Celastraceae). Their structures have been elucidated, through the application of 1D and 2D nmr spectroscopic methods, as 20,29-dihydroxy-3-oxolupan-30,21 alpha-olide (ochraceolide D) [1] and 28-hydroxy-3-oxolup-20(2...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1993-10, Vol.56 (10), p.1676-1681
Main Authors: Ngassapa, Olipa, Soejarto, Djaja D, Pezzuto, John M, Farnsworth, Norman R, Che, Chun-Tao
Format: Article
Language:English
Subjects:
agentes antineoplasticos
Animals
antineoplastic agents
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
bark products
Biological and medical sciences
celastraceae
Drug Screening Assays, Antitumor
extractos vegetales
extrait d' origine vegetale
farmacologia
General pharmacology
Humans
lactonas
lactone
lactones
Leukemia P388 - drug therapy
Magnetic Resonance Spectroscopy
Medical sciences
medicament cytostatique
Mice
Pharmacognosy. Homeopathy. Health food
pharmacologie
pharmacology
Pharmacology. Drug treatments
plant extracts
Plants, Medicinal - chemistry
produit a base d' ecorce
Spectrophotometry, Infrared
stems
tallo
tige
Triterpenes - chemistry
Triterpenes - pharmacology
trozos de corteza
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Summary:Additional new lupane lactones were isolated from the stem bark of Kokoona ochracea (Celastraceae). Their structures have been elucidated, through the application of 1D and 2D nmr spectroscopic methods, as 20,29-dihydroxy-3-oxolupan-30,21 alpha-olide (ochraceolide D) [1] and 28-hydroxy-3-oxolup-20(29)-en-30,21 alpha-olide (ochraceolide E) [2]. These compounds and the mono- and di-acetates of ochraceolide D (4 and 5, respectively) were evaluated for in vitro cytotoxic activity against P-388 murine lymphocytic leukemia cells and a panel of human cancer cell systems. Ochraceolide D [1] was significantly cytotoxic (ED50, 3.9 micrograms/ml) against human glioblastoma (U373) cells. Other compounds (4, 5, and 2) exhibited only a weak cytotoxic response in certain cancer cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50100a003