Widespread Distribution of Brain Dopamine Receptors Evidenced with [$^{125}$I]Iodosulpride, a Highly Selective Ligand

The new benzamide derivative [$^{125}$I]iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors and displays a very low nonspecific binding to membrane or autoradiographic sections. On autoradiographic images, D-2 receptors are present not only in well-established dopamine...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1985-05, Vol.228 (4700), p.752-755
Main Authors: Martres, Marie-Pascale, Bouthenet, Marie-Louise, Sales, Nicole, Sokoloff, Pierre, Schwartz, Jean-Charles
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Benzamides
Biological and medical sciences
Brain - physiology
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Cerebellum
Cerebellum - physiology
Cerebral Cortex - physiology
Dopamine receptors
Entorhinal cortex
Fundamental and applied biological sciences. Psychology
Hippocampus - physiology
Inhibitory concentration 50
Innervation
Iodine Radioisotopes
Ligands
Motor Cortex - physiology
Pharmacology
Rats
Receptors
Receptors, Dopamine - metabolism
Receptors, Dopamine - physiology
Substantia nigra
Sulpiride - analogs & derivatives
Sulpiride - metabolism
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The new benzamide derivative [$^{125}$I]iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors and displays a very low nonspecific binding to membrane or autoradiographic sections. On autoradiographic images, D-2 receptors are present not only in well-established dopaminergic areas but also, in a discrete manner, in a number of catecholaminergic regions in which the dopaminergic innervation is still unknown, imprecise, or controversial, as in the sensorimotor cerebral cortex or cerebellum. This widespread distribution suggests larger physiological and pathophysiological roles for cerebral dopamine receptors than was previously thought.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3838821