Family History, Age, and Risk of Fatal Breast Cancer

A family history of breast cancer potentially identifies women at high risk for whom mammography may be especially valuable. The authors examined the association of fatal breast cancer and family history in a large, prospective study of US adults. After 6 years of follow-up, 880 cases of fatal breas...

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Bibliographic Details
Published in:American journal of epidemiology 1993-11, Vol.138 (9), p.675-681
Main Authors: Calle, Eugenia E., Martin, Linda M., Thun, Michael J., Miracle, Heidi L., Heath, Clark W.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Biological and medical sciences
breast neoplasms
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Breast Neoplasms - mortality
cohort studies
Female
genetics
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Menopause
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
risk
Risk Factors
Tumors
United States - epidemiology
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Summary:A family history of breast cancer potentially identifies women at high risk for whom mammography may be especially valuable. The authors examined the association of fatal breast cancer and family history in a large, prospective study of US adults. After 6 years of follow-up, 880 cases of fatal breast cancer were observed in a cohort of 604,412 women who were cancer free at interview in 1982. Cox proportional hazards modeling found that a family history of breast cancer in a mother or sister was significantly related to fatal breast cancer risk (rate ratio=1.59, 95% confidence interval (Cl) 1.29–1.95). The association was greatly modified by age; the rate ratio was 4.91 (95% Cl 1.39–17.3) in women aged
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a116904