Antimicrobial prophylaxis in hysterectomies : a double-blind, randomized, comparative study of a single dose of piperacillin (2g) versus a single dose of amoxicillin-clavulanic acid (2.2 g)

A double-blind, randomized comparative study of piperacillin (2 g) versus amoxicillin-clavulanic acid (2.2 g) as a single dose 30 minutes before the initiation of hysterectomy was performed. A total of 595 patients (of which 307 were in the piperacillin group) were evaluable for efficacy. Infectious...

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Bibliographic Details
Published in:Infection 1993-07, Vol.21 (4), p.214-219
Main Authors: JANKNEGT, R, SCHEPERS, J, HAEST, J, FABIUS, G, LOHMAN, J
Format: Article
Language:English
Subjects:
Amoxicillin - administration & dosage
Amoxicillin - therapeutic use
Amoxicillin-Potassium Clavulanate Combination
Biological and medical sciences
Clavulanic Acids - administration & dosage
Clavulanic Acids - therapeutic use
Double-Blind Method
Drug Therapy, Combination - administration & dosage
Drug Therapy, Combination - therapeutic use
Female
Fever - drug therapy
Fever - epidemiology
Fever - microbiology
Humans
Hysterectomy - methods
Incidence
Infection - drug therapy
Infection - epidemiology
Infection - microbiology
Infusions, Intravenous
Medical sciences
Miscellaneous
Piperacillin - administration & dosage
Piperacillin - therapeutic use
Postoperative Complications - drug therapy
Postoperative Complications - epidemiology
Postoperative Complications - microbiology
Postoperative Complications - prevention & control
Premedication - methods
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
Urinary Catheterization - adverse effects
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Summary:A double-blind, randomized comparative study of piperacillin (2 g) versus amoxicillin-clavulanic acid (2.2 g) as a single dose 30 minutes before the initiation of hysterectomy was performed. A total of 595 patients (of which 307 were in the piperacillin group) were evaluable for efficacy. Infectious complications were infrequent in both arms. One case of (mild) sepsis was observed in the piperacillin group and two cases of wound infection were observed in the amoxicillin-clavulanic acid group. Urinary tract infection was observed in 5.5% of the patients in the piperacillin group and in 2.4% of the amoxicillin-clavulanic acid group. A relatively high incidence of asymptomatic bacteriuria was seen in both groups: 11.8% in the piperacillin group and 8.7% with amoxicillin-clavulanic acid. A marked difference was seen between the two different hospital locations: a 15% incidence in the hospital where midstream urine was used for culture (Sittard), versus 5% in the hospital where catheter urine was used (Geleen). It is concluded that both antibiotics are associated with a low rate of infectious complications and that catheter urine must be used for sample collection.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01728891