Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss

To establish the prevalence of hyperhomocysteinemia in women with unexplained recurrent early pregnancy loss. In a patient-control study, the methionine-homocysteine metabolism was investigated by a standardized oral methionine-loading test. Gynecologic outpatient department of university hospital....

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Bibliographic Details
Published in:Fertility and sterility 1993-11, Vol.60 (5), p.820-825
Main Authors: Wouters, Maurice G.A.J., Boers, Godfried H.J., Blom, Henk J., Trijbels, Frans J.M., Thomas, Chris M.G., Borm, George F., Steegers-Theunissen, Régine P.M., Eskes, Tom K.A.B.
Format: Article
Language:English
Subjects:
Abortion, Habitual - blood
Abortion, Habitual - epidemiology
Adult
Amino Acid Metabolism, Inborn Errors - blood
Amino Acid Metabolism, Inborn Errors - complications
Amino Acid Metabolism, Inborn Errors - epidemiology
Biological and medical sciences
Birth control
Case-Control Studies
Female
folate
Gynecology. Andrology. Obstetrics
habitual abortion
Homocysteine
Homocysteine - blood
Homocysteine - metabolism
Humans
Medical sciences
Methionine - metabolism
Middle Aged
Pregnancy
Pregnancy Trimester, First
Prevalence
Risk Factors
Sterility. Assisted procreation
vitamin B12
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Summary:To establish the prevalence of hyperhomocysteinemia in women with unexplained recurrent early pregnancy loss. In a patient-control study, the methionine-homocysteine metabolism was investigated by a standardized oral methionine-loading test. Gynecologic outpatient department of university hospital. One-hundred and two women who had been referred to the hospital because they suffered from at least two consecutive unexplained spontaneous abortions (study group) as well as 41 controls who were recruited by public advertisement were selected. Blood samples were collected just before and 6hours after oral methionine administration to determine plasma total homocysteine concentrations. Plasma total homocysteine concentrations 6hours after methionine loading. Hyperhomocysteinemia was defined as total homocysteine concentration at 6hours exceeding the 97.5 percentile level of the controls. Hyperhomocysteinemia was diagnosed in 21 women of the study group (21%). In the parous women of the study group, the prevalence of hyperhomocysteinemia was more than two times greater compared with the nulliparous subjects (33% and 14%, respectively). Hyperhomocysteinemia is a risk factor in women with unexplained recurrent early pregnancy loss.
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(16)56282-7