Analysis and sorting of chromosomes by flow cytometry: New trends

Flow cytogenetic is widely used since 1975, and essentially contributes to caryotype analysis and chromosome sorting. The principles of experimentation and its possibilities and limitations are now well known. Recently several new technologies have appeared. What attitude should the cytometrist adop...

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Bibliographic Details
Published in:Biology of the cell 1993, Vol.78 (1), p.31-39
Main Authors: Métézeau, Philippe, Schmitz, Annette, Frelat, Gerard
Format: Article
Language:English
Subjects:
Animals
Cell Fractionation - methods
Cell Line
Chromosomes
Chromosomes, Human
Cytogenetics - instrumentation
Cytogenetics - methods
Cytogenetics - trends
cytometry
DNA - analysis
Eukaryotic Cells - ultrastructure
Female
Flow Cytometry - instrumentation
Flow Cytometry - methods
Flow Cytometry - trends
genetics
Humans
karyotype
Karyotyping - methods
Male
Micromanipulation
Specimen Handling
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Summary:Flow cytogenetic is widely used since 1975, and essentially contributes to caryotype analysis and chromosome sorting. The principles of experimentation and its possibilities and limitations are now well known. Recently several new technologies have appeared. What attitude should the cytometrist adopt regarding PCR, microdissection of chromosomes, in situ hybridization, slit-scan flow cytometry or image analysis?
ISSN:0248-4900
1768-322X
DOI:10.1016/0248-4900(93)90112-R