Effects of andrographolide on sexual functions, vascular reactivity and serum testosterone level in rodents

In this study, effects of andrographolide from Andrographis paniculata on sexual functions, vascular reactivity and serum testosterone level in experimental animals were observed. The suspension of andrographolide in 5% DMSO was administered orally at the dose of 50mg/kg to male ICR mice. The female...

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Bibliographic Details
Published in:Food and chemical toxicology 2010-07, Vol.48 (7), p.1934-1938
Main Authors: Sattayasai, Jintana, Srisuwan, Supawadee, Arkaravichien, Tarinee, Aromdee, Chantana
Format: Article
Language:English
Subjects:
Andrographis paniculata
Andrographolide
Animals
Aorta, Thoracic - drug effects
Biological and medical sciences
Blood Vessels - drug effects
Diterpenes - pharmacology
Female
In Vitro Techniques
Male
Male mice
Medical sciences
Mice
Mice, Inbred ICR
Muscle Contraction - drug effects
Muscle, Smooth, Vascular - drug effects
Piperazines - pharmacology
Purines - pharmacology
Rats
Rats, Sprague-Dawley
Sexual Behavior, Animal - drug effects
Sexual function
Sildenafil Citrate
Sperm Count
Sperm Motility - drug effects
Sulfones - pharmacology
Testosterone
Testosterone - blood
Toxicology
Vascular reactivity
Vasodilator Agents - pharmacology
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Summary:In this study, effects of andrographolide from Andrographis paniculata on sexual functions, vascular reactivity and serum testosterone level in experimental animals were observed. The suspension of andrographolide in 5% DMSO was administered orally at the dose of 50mg/kg to male ICR mice. The female mice involved in mating were made receptive by hormonal treatment. The mating behaviors, mounting latency and mounting frequency, were determined and compared with the standard reference drug sildenafil citrate. Administration of andrographolide significantly decreased the mounting latency at 120 and 180min and increased mounting frequency at 180min after treatment. In endothelium-intact rat aortic strips, norepineprine-induced contraction was reduced by preincubation with andrographolide. Administration of 50mg/kg andrographolide orally to male mice once daily for 2, 4, 6 or 8weeks had no significant effects on sperm morphology and motility. Interestingly, at week 4, serum testosterone level in mice treated with andrographolide was significantly increased when compared to the control. Thus, the effects of andrographolide on vascular response to norepinephrine and testosterone level observed in this study might be contributed to the sexual enhancing properties observed.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2010.04.037