Protein composition determines the anti-atherogenic properties of HDL in transgenic mice

High-density lipoprotein (HDL) contains two major proteins, apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), comprising about 70% and 20% of the total HDL protein mass, respectively. HDL exists in human plasma in two main forms, one containing apoA-I with apoA-II (AI/AII-HDL) and anoth...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1993-10, Vol.365 (6448), p.762-764
Main Authors: Schultz, Joshua R, Verstuyft, Judy G, Gong, Elaine L, Nichols, Alex V, Rubin, Edward M
Format: Article
Language:English
Subjects:
Animals
Apolipoprotein A-I - physiology
Apolipoprotein A-II - physiology
Arteriosclerosis - etiology
Atherosclerosis (general aspects, experimental research)
Biochemistry
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Disease
Disease Susceptibility
Female
Humans
Lipoproteins, HDL - chemistry
Lipoproteins, HDL - genetics
Lipoproteins, HDL - physiology
Male
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Transgenic
Proteins
Rodents
Transgenic animals
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High-density lipoprotein (HDL) contains two major proteins, apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), comprising about 70% and 20% of the total HDL protein mass, respectively. HDL exists in human plasma in two main forms, one containing apoA-I with apoA-II (AI/AII-HDL) and another containing apoA-I without apoA-II (AI-HDL). A strong inverse relationship exists between total plasma HDL concentration and atherosclerosis, but the results of studies examining the relationship between AI-HDL and AI/AII-HDL and atherosclerosis have been conflicting. To determine whether these two HDL populations have different effects on atherogenesis, human apoA-I (AI) and human apoA-I and apoA-II (AI/AII) transgenic mice were produced in an atherosclerosis-susceptible strain. Following an atherogenic diet, despite similar total cholesterol and HDL cholesterol concentrations, the area of atherogenic lesions in the AI/AII mice was 15-fold greater than in the AI animals. These studies show that the protein composition of HDL significantly affects its role in atherogenesis and that AI-HDL is more antiatherogenic than AI/AII-HDL.
ISSN:0028-0836
1476-4687
DOI:10.1038/365762a0