A novel CYP1A1 gene polymorphism in African-Americans

A new Mspl RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A-T to G-C transition in the 3' noncoding region ˜300 bp upstream from the polyadenylation site. This mutation leads to cleavage of the normal 2.3 kb Mspl restriction...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1993-09, Vol.14 (9), p.1729-1731
Main Authors: Crofts, Frances, Cosma, Greg N., Currie, Diane, Taioli, Emanuela, Toniolo, Paolo, Garte, Seymour J.
Format: Article
Language:English
Subjects:
African Continental Ancestry Group - genetics
Asia - ethnology
Base Sequence
Biological and medical sciences
Cytochrome P-450 Enzyme System - genetics
Epidemiology
European Continental Ancestry Group - genetics
Exons - genetics
Humans
Medical sciences
Molecular Sequence Data
Polymorphism, Genetic - genetics
Polymorphism, Restriction Fragment Length
Sequence Analysis, DNA
Tumors
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Description
Summary:A new Mspl RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A-T to G-C transition in the 3' noncoding region ˜300 bp upstream from the polyadenylation site. This mutation leads to cleavage of the normal 2.3 kb Mspl restriction fragment into 1.3 and 1.0 kb fragments. The heterozygous mutation has been seen in 8 of 47 African-Americans, but was not detected in 191 Caucasians or 30 Asians. No linkage was observed with either of the two previously described polymorphisms in this gene.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/14.9.1729