Screening Tests for Blood Donors Presumed to Have Transmitted the Acquired Immunodeficiency Syndrome

We investigated 18 sets of blood donors from 12 to 50 months after they donated blood to recipients who subsequently developed the acquired immunodeficiency syndrome (AIDS). Within each donor set, only one donor was suspected of having transmitted the disease (ie, member of an AIDS risk group). The...

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Bibliographic Details
Published in:Blood 1985-03, Vol.65 (3), p.772-775
Main Authors: McDougal, J. Steven, Jaffe, Harold W., Cabridilla, Cirilo D., Sarngadharan, M.G., Nicholson, Janet K.A., Kalyanaraman, V.S., Schable, Charles A., Kilbourne, Barbara, Evatt, Bruce L., Gallo, Robert C., Curran, James W.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - diagnosis
Acquired Immunodeficiency Syndrome - transmission
AIDS/HIV
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antibodies, Viral - analysis
Biological and medical sciences
Blood Donors
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Carrier State - diagnosis
Hepatitis B Antibodies - analysis
Hepatitis B Core Antigens - analysis
Humans
Mass Screening
Medical sciences
Retroviridae - immunology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - immunology
Transfusion Reaction
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Description
Summary:We investigated 18 sets of blood donors from 12 to 50 months after they donated blood to recipients who subsequently developed the acquired immunodeficiency syndrome (AIDS). Within each donor set, only one donor was suspected of having transmitted the disease (ie, member of an AIDS risk group). The other donors (n = 189) were not risk group members and served as controls. A number of laboratory tests distinguished suspected from nonsuspected donors, including determination of T helper /T suppressor cell ratio, antibody to hepatitis B core antigen, and immune complexes, but none of these was as sensitive and specific as tests for antibody to the human retrovirus, HTLV-III/LAV.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V65.3.772.772