Methylenetetrahydrofolate reductase C677T gene polymorphism in turkish patients with polycystic ovary syndrome

Higher Levels of Hcy are associated with several clinical conditions, among them non-insulin-dependent diabetes mellitus, endometrial dysplasia and hypertension with insulin resistance, and polycystic ovary syndrome. The purpose of this study was to investigate the serum homocystein levels and other...

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Bibliographic Details
Published in:Endocrine 2010-08, Vol.38 (1), p.127-133
Main Authors: Karadeniz, Muammer, Erdogan, Mehmet, Zengi, Ayhan, Eroglu, Zuhal, Tamsel, Sadik, Olukman, Murat, Saygili, Fusun, Yilmaz, Candeger
Format: Article
Language:English
Subjects:
Adult
Diabetes
Endocrinology
Female
Gene Frequency
Genotype
Homocysteine - blood
Humanities and Social Sciences
Humans
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - genetics
Internal Medicine
Medicine
Medicine & Public Health
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
multidisciplinary
Original Article
Polycystic Ovary Syndrome - genetics
Polymorphism, Genetic
Science
Turkey
Young Adult
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Summary:Higher Levels of Hcy are associated with several clinical conditions, among them non-insulin-dependent diabetes mellitus, endometrial dysplasia and hypertension with insulin resistance, and polycystic ovary syndrome. The purpose of this study was to investigate the serum homocystein levels and other metabolic parameters in relationship with the MTHFR C677T gene polymorphism in patients with PCOS. Our study included 86 young women with PCOS constituting the study group and 70 healthy women constituting the control group. Homocystein levels, metabolic, and hormonal parameters were measured, and genetic analysis of the MTHFR C677T gene polymorphism was performed in all the subjects. A statistically significant difference was observed in mean homocystein levels between patients with PCOS when compared to the control group. The MTHFR 677 CC genotypes had significantly higher proportions in the control group compared to the PCOS patients (χ 2  = 21.381, P  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-010-9370-0