A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl controlled by Hox-C8 in vivo

The homeobox is a 183-base-pair DNA sequence originally found in Drosophila segmentation and homeotic genes. In Drosophila, homeotic genes are clustered in the Antennapedia and Bithorax complexes, collectively called the homeotic gene complex (HOM-C). In the mouse genome, about 40 homeobox genes (Ho...

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Bibliographic Details
Published in:Nature (London) 1993-09, Vol.365 (6441), p.69-72
Main Authors: Tomotsune, Daihachiro, Shoji, Hiroki, Wakamatsu, Yoshio, Kondoh, Hisato, Takahashi, Naoki
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
DNA
DNA-Binding Proteins - genetics
Drosophila
Drosophila melanogaster
Drosophila Proteins
Embryo, Mammalian
Embryo, Nonmammalian
Gene Expression Regulation
Genes, Homeobox
Genes, Tumor Suppressor
Homeodomain Proteins
Insect Hormones - genetics
Larva
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Molecular Sequence Data
Proteins - genetics
Sequence Alignment
Spinal Cord - metabolism
Tumor Suppressor Proteins
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Summary:The homeobox is a 183-base-pair DNA sequence originally found in Drosophila segmentation and homeotic genes. In Drosophila, homeotic genes are clustered in the Antennapedia and Bithorax complexes, collectively called the homeotic gene complex (HOM-C). In the mouse genome, about 40 homeobox genes (Hox) are clustered in four chromosomal regions (Hox A to D). The Hox genes are arranged in the same order and have the same anteroposterior pattern of expression as their structural homologue in the HOM-C, suggesting that they control mouse pattern formation in the same way that HOM-C members do in Drosophila. Homeobox gene products are believed to be transcription factors that regulate expression of target genes. A few candidate target genes have been identified in Drosophila by various approaches but the Hox gene targets are poorly understood, mostly because of limitations in the available approaches. Here we identify several candidate Hox gene targets, including a mouse homologue of the Drosophila tumour-suppressor gene l(2)gl, by immunopurification of DNA sequences bound to a Hox protein in native chromatin.
ISSN:0028-0836
1476-4687
DOI:10.1038/365069a0