Immunohistochemical expression of SHH, PTC, SMO and GLI1 in glandular odontogenic cysts and dentigerous cysts

Oral Diseases (2010) 16, 818–822 Objective:  To investigate expression of the sonic hedgehog (SHH) signaling pathway components in glandular odontogenic cysts (GOCs), and dentigerous cysts (DCs). MATIERIALS AND METHODS: Immunohistochemical staining for SHH, patched (PTC), smoothened (SMO), and the t...

Full description

Saved in:
Bibliographic Details
Published in:Oral diseases 2010-11, Vol.16 (8), p.818-822
Main Authors: Zhang, L, Sun, ZJ, Chen, XM, Chen, Z
Format: Article
Language:English
Subjects:
Cell Count
Coloring Agents
Connective Tissue - pathology
Cytoplasm - ultrastructure
Dentigerous Cyst - pathology
Dentistry
Epithelial Cells - pathology
Epithelium - pathology
Fibroblasts - pathology
glandular odontogenic cysts
GLI1
Hedgehog Proteins - analysis
Humans
Immunohistochemistry
Mucous Membrane - pathology
Odontogenic Cysts - pathology
Patched Receptors
PTC
Receptors, Cell Surface - analysis
Receptors, G-Protein-Coupled - analysis
SHH
SMO
Smoothened Receptor
Transcription Factors - analysis
Zinc Finger Protein GLI1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oral Diseases (2010) 16, 818–822 Objective:  To investigate expression of the sonic hedgehog (SHH) signaling pathway components in glandular odontogenic cysts (GOCs), and dentigerous cysts (DCs). MATIERIALS AND METHODS: Immunohistochemical staining for SHH, patched (PTC), smoothened (SMO), and the transcriptional factor GLI1 were investigated in the 12 GOCs specimens and 20 DCs. Results:  In GOCs and DCs, immunoreactivity for SHH, PTC, SMO, and GLI1 were detected in the epithelial cytoplasm. Each of the genes of the SHH signaling pathway was expressed in similar patterns in the epithelial lining of the cysts. The expression of SHH, PTC, SMO, and GLI1 was significantly higher in epithelia than that of subepithelial fibroblasts (P 
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2010.01697.x