The Impact of Endurance Exercise Training on Left Ventricular Torsion

Objectives We sought to examine the effect of endurance exercise training (EET) on peak systolic left ventricular torsion (LVT) and peak early diastolic untwisting rate (UTR). Background Left ventricular (LV) structural adaptations to EET have been well characterized. LVT, a recognized marker of LV...

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Published in:JACC. Cardiovascular imaging 2010-10, Vol.3 (10), p.1001-1009
Main Authors: Weiner, Rory B., MD, Hutter, Adolph M., MD, Wang, Francis, MD, Kim, Jonathan, MD, Weyman, Arthur E., MD, Wood, Malissa J., MD, Picard, Michael H., MD, Baggish, Aaron L., MD
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adolescent
Biomechanical Phenomena
Cardiovascular
Echocardiography, Doppler, Color
Echocardiography, Doppler, Pulsed
Heart Ventricles - diagnostic imaging
Humans
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - physiopathology
Longitudinal Studies
Male
Physical Endurance
Prospective Studies
Resistance Training
Time Factors
Torsion, Mechanical
Ventricular Function, Left
Young Adult
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Summary:Objectives We sought to examine the effect of endurance exercise training (EET) on peak systolic left ventricular torsion (LVT) and peak early diastolic untwisting rate (UTR). Background Left ventricular (LV) structural adaptations to EET have been well characterized. LVT, a recognized marker of LV function in numerous cardiac diseases, has recently been investigated in the setting of exercise. However, longitudinal data characterizing the impact of sustained exercise training on LVT have not been reported. Methods A prospective, longitudinal study design examined the impact of a 90-day period of training on LV twist mechanics in university male rowers (n = 15, mean age 18.6 ± 0.5 years). Conventional LV structural measurements, LV apical and basal rotation, peak systolic LVT, and peak early diastolic UTR were measured by 2-dimensional and speckle tracking echocardiography before and after the EET study period. Results Participants experienced LV eccentric hypertrophy, characterized by increased LV end-diastolic volume (80.8 ± 8.7 ml/m2 vs. 91.3 ± 8.0 ml/m2 , p < 0.001) and LV mass (101.3 ± 11.4 g/m2 vs. 115.7 ± 12.6 g/m2 , p = 0.001). There was a significant increase in peak systolic apical rotation (8.9 ± 4.2° vs. 12.7 ± 3.9°, p = 0.002) but no change in basal rotation. This translated into a highly significant increase in peak systolic LVT after EET (14.1 ± 5.0° vs. 18.0 ± 3.6°, p = 0.002). The impact of EET on LV twist mechanics was not confined to ventricular systole, as peak early diastolic UTR (−110.6 ± 41.8°/s vs. −148.0 ± 29.8°/s, p = 0.003) and the percentage of untwisting that occurred by the end of isovolumic relaxation (31.2 ± 12.0% vs. 39.9 ± 14.9%, p = 0.04) increased. Conclusions Participation in EET was associated with significant changes in LV twist mechanics characterized by increased apical rotation, LVT, and UTR. These findings suggest that LVT and UTR augmentation may be an important and previously unrecognized component of exercise-induced cardiac remodeling.
ISSN:1936-878X
1876-7591
DOI:10.1016/j.jcmg.2010.08.003