Platinum-DNA adduct in leukocyte DNA of a cohort of 49 patients with 24 different types of malignancies

Using atomic absorbance spectrometry with Zeeman background correction, we measured platinum-DNA adduct levels in leukocyte DNA of 49 patients receiving therapy consisting of only carboplatin and cisplatin. Twenty-four histological types of malignancy were included in the cohort. Peripheral blood le...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1993-08, Vol.53 (16), p.3694-3699
Main Authors: REED, E, PARKER, R. J, GILL, I, BICHER, A, DABHOLKAR, M, VIONNET, J. A, BOSTICK-BRUTON, F, TARONE, R, MUGGIA, F. M
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Carboplatin - metabolism
Carboplatin - therapeutic use
Cisplatin - analysis
Cisplatin - blood
DNA - analysis
DNA - blood
DNA Adducts
General aspects
Humans
Leukocytes - chemistry
Leukocytes - metabolism
Medical sciences
Neoplasms - blood
Neoplasms - drug therapy
Pharmacology. Drug treatments
Prospective Studies
Spectrophotometry, Atomic
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Using atomic absorbance spectrometry with Zeeman background correction, we measured platinum-DNA adduct levels in leukocyte DNA of 49 patients receiving therapy consisting of only carboplatin and cisplatin. Twenty-four histological types of malignancy were included in the cohort. Peripheral blood leukocytes were collected at defined times during the first two cycles of treatment. The relationship between adduct level and disease response was highly statistically significant during cycle 1 of therapy (two-sided P = 0.007 at day 2), but statistical significance was lost during cycle 2. On all days studied, median and mean adduct levels were consistently higher in responders as compared to nonresponders (summary two-sided P = 0.0004). These data suggest that the processes which protect cellular DNA may be common to malignant and nonmalignant rapidly dividing tissues of the same individual, regardless of the type of tumor that individual may harbor.
ISSN:0008-5472
1538-7445