Supervised exercise training improves cardiopulmonary fitness in HIV-infected persons

We attempted to measure cardiopulmonary effects, CD4 counts, and perceived sense of well-being in 25 individuals moderately to severely immunocompromised from HIV infection (mean entry CD4 count = 144.microliters-1) before and after a 24-wk program of exercise training. Only six subjects completed t...

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Bibliographic Details
Published in:Medicine and science in sports and exercise 1993-06, Vol.25 (6), p.684-688
Main Authors: MACARTHUR, R. D, LEVINE, S. D, BIRK, T. J
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - physiopathology
Acquired Immunodeficiency Syndrome - psychology
Adult
AIDS-Related Complex - immunology
AIDS-Related Complex - physiopathology
AIDS-Related Complex - psychology
AIDS/HIV
Biological and medical sciences
Blood Pressure - physiology
CD4-Positive T-Lymphocytes - pathology
Energy Metabolism
Exercise
Exercise Therapy
Feasibility Studies
Female
Heart - physiology
Heart Rate - physiology
HIV Infections - immunology
HIV Infections - physiopathology
HIV Infections - psychology
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Leukocyte Count
Lung - physiology
Male
Medical sciences
Mental Health
Patient Compliance
Physical Fitness
Pilot Projects
Space life sciences
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Summary:We attempted to measure cardiopulmonary effects, CD4 counts, and perceived sense of well-being in 25 individuals moderately to severely immunocompromised from HIV infection (mean entry CD4 count = 144.microliters-1) before and after a 24-wk program of exercise training. Only six subjects completed the 24-wk program. All six showed evidence of a training effect. Statistically significant improvements were seen in maximal oxygen consumption (VO2max), oxygen pulse, and minute ventilation. Submaximal exercise performance improved significantly by 12 wk in the 10 individuals available for testing: decreases were seen in heart rate, rate pressure product, and rate of perceived exertion. White blood cell counts and T-lymphocyte subsets were stable at 12 and 24 wk in the subjects available for testing. High depression/anxiety scores on a mental health inventory (General Health Questionnaire) correlated with low CD4 counts. Scores did not correlate with compliance with the exercise program. There was a trend (P < 0.10) for scores to improve over time among those individuals who attended > or = 80% of scheduled exercise sessions. We conclude that exercise training is feasible and beneficial for some HIV-infected individuals.
ISSN:0195-9131
1530-0315
DOI:10.1249/00005768-199306000-00006