SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE CHAIN

Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-l-propen-l-yl]cephalosporin (10) showed excellent activity against G...

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Bibliographic Details
Published in:Journal of antibiotics 1993/05/25, Vol.46(5), pp.833-839
Main Authors: OKITA, TAKAAKI, IMAE, KIYOTO, HASEGAWA, TOSHIFUMI, IIMURA, SEIJI, MASUYOSHI, SHINJI, KAMACHI, HAJIME, KAMEI, HIDEO
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cephalosporins - chemical synthesis
Cephalosporins - pharmacology
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Structure-Activity Relationship
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Summary:Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-l-propen-l-yl]cephalosporin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.833