Use of Sonication for the Coupling of Sterically Hindered Substrates in the Phenolic Mitsunobu Reaction

A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.

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Bibliographic Details
Published in:Journal of organic chemistry 2003-10, Vol.68 (21), p.8261-8263
Main Authors: Lepore, Salvatore D, He, Yuanjun
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Noncondensed benzenic compounds
Organic chemistry
Preparations and properties
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Description
Summary:A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo0345751