Disturbances in collagen synthesis in trisomic cells from spontaneously aborted embryos

Collagen synthesis in cells with trisomy 7 and 9 derived from human spontaneous abortuses was found to be lower (5.06% and 5.53% respectively) than in the control diploid cells (8.80%). The ratio of collagen types (I/III) in trisomic strains did not differ from the control data while the amount of t...

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Bibliographic Details
Published in:Human genetics 1984-01, Vol.68 (3), p.269-271
Main Authors: KUKHARENKO, V. I, DELVIG, A. A, GRINBERG, K. N
Format: Article
Language:English
Subjects:
Abortion, Spontaneous
Biological and medical sciences
Cells, Cultured
Chromosome aberrations
Chromosomes, Human, 6-12 and X
Collagen - biosynthesis
Collagen - genetics
Embryo, Mammalian - metabolism
Extracellular Matrix - metabolism
Female
Fibroblasts
Humans
Male
Medical genetics
Medical sciences
Pregnancy
Trisomy
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Summary:Collagen synthesis in cells with trisomy 7 and 9 derived from human spontaneous abortuses was found to be lower (5.06% and 5.53% respectively) than in the control diploid cells (8.80%). The ratio of collagen types (I/III) in trisomic strains did not differ from the control data while the amount of the degraded procollagen in trisomic cells was increased.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00418401