Recovery of microalgal biomass and metabolites: process options and economics

Commercial production of intracellular microalgal metabolites requires the following: (1) large-scale monoseptic production of the appropriate microalgal biomass; (2) recovery of the biomass from a relatively dilute broth; (3) extraction of the metabolite from the biomass; and (4) purification of th...

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Bibliographic Details
Published in:Biotechnology advances 2003, Vol.20 (7), p.491-515
Main Authors: Molina Grima, E, Belarbi, E.-H, Acién Fernández, F.G, Robles Medina, A, Chisti, Yusuf
Format: Article
Language:English
Subjects:
Algae
algal culture
Algal culture (microalgae)
Biological and medical sciences
Biomass recovery
Biotechnology
Eicosapentaenoic acid
Flocculation
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microalgae
Phaeodactylum tricornutum
photobioreactors
Process economics
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Summary:Commercial production of intracellular microalgal metabolites requires the following: (1) large-scale monoseptic production of the appropriate microalgal biomass; (2) recovery of the biomass from a relatively dilute broth; (3) extraction of the metabolite from the biomass; and (4) purification of the crude extract. This review examines the options available for recovery of the biomass and the intracellular metabolites from the biomass. Economics of monoseptic production of microalgae in photobioreactors and the downstream recovery of metabolites are discussed using eicosapentaenoic acid (EPA) recovery as a representative case study.
ISSN:0734-9750
1873-1899
DOI:10.1016/S0734-9750(02)00050-2