Detection of pulmonary nodules by multislice computed tomography: improved detection rate with reduced slice thickness

The purpose of this study was to find out if the use of 1.25-mm collimated thin-slice technique helps to detect more small pulmonary lung nodules than the use of 5 mm. A total of 100 patient examinations that allowed a reconstruction of 1.25-mm slice thickness in addition to the standard of 5-mm sli...

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Bibliographic Details
Published in:European radiology 2003-10, Vol.13 (10), p.2378-2383
Main Authors: Fischbach, Frank, Knollmann, Friedrich, Griesshaber, Volker, Freund, Torsten, Akkol, Ethem, Felix, Roland
Format: Article
Language:English
Subjects:
Adult
Aged
Agreements
Cohort Studies
Confidence Intervals
Female
Humans
Imaging, Three-Dimensional
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Male
Middle Aged
Neoplasm Staging
Observer Variation
Radiographic Image Interpretation, Computer-Assisted - methods
Sampling Studies
Sensitivity and Specificity
Solitary Pulmonary Nodule - diagnostic imaging
Solitary Pulmonary Nodule - pathology
Studies
Tomography, X-Ray Computed - methods
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Summary:The purpose of this study was to find out if the use of 1.25-mm collimated thin-slice technique helps to detect more small pulmonary lung nodules than the use of 5 mm. A total of 100 patient examinations that allowed a reconstruction of 1.25-mm slice thickness in addition to the standard of 5-mm slices were included in a prospective study. Acquisition technique included four rows of 1-mm slices. Two sets of contiguous images were reconstructed and compared with 1.25- and 5-mm slice thickness, respectively. Two radiologists performed a film-based analysis of the images. The size and the confidence of the seen nodules were reported. We did not perform a histological verification, according to the normal clinical procedure, although it would be optimal regarding research. Statistical analysis was performed by using longitudinal analysis described by Brunner and Langer. In addition, sensitivity, specificity, negative predictive value and positive predictive value were calculated for each reader using the 1.25-mm sections as the gold standard. As an index for concordance the kappa value was used. A value of p
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-003-1915-7