Self-Immolative Dendrimers

Docking the tails: The triggering of a single cleavage at the core of a new class of dendrimers (see, for example, the second generation dendron) results in a spontaneous chain fragmentation and the release all of the tail (reporter) units. Such dendrimers may be applied as a general platform for pr...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2003-09, Vol.42 (37), p.4494-4499
Main Authors: Amir, Roey J., Pessah, Neta, Shamis, Marina, Shabat, Doron
Format: Article
Language:English
Subjects:
amides
dendrimers
dyes
fragmentation
rearrangement
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Summary:Docking the tails: The triggering of a single cleavage at the core of a new class of dendrimers (see, for example, the second generation dendron) results in a spontaneous chain fragmentation and the release all of the tail (reporter) units. Such dendrimers may be applied as a general platform for prodrugs or sensor molecules for enzymatic activity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200351962