Dose Titration of Sustained-Release Recombinant Bovine Somatotropin in Lactating Dairy Cows

Lactating dairy cows (n = 264) were used in seven dose titration experiments at four geographic locations in the United States. A sustained-release formulation of recombinant bST was evaluated f or a 30-wk treatment period that began 14 wk postpartum. The first series of four experiments evaluated d...

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Bibliographic Details
Published in:Journal of dairy science 1993-04, Vol.76 (4), p.1125-1136
Main Authors: Downer, J.V., Patterson, D.L., Rock, D.W., Chalupa, W.V., Cleale, R.M., Firkins, J.L., Lynch, G.L., Clark, J.H., Brodie, B.O., Jenny, B.F., De Gregorio, R.
Format: Article
Language:English
Subjects:
animal health
Animals
application methods
body condition
bovine mastitis
Cattle
Cattle Diseases - epidemiology
chemical composition
composicion quimica
composition chimique
condicion corporal
dairy cows
Delayed-Action Preparations
etat corporel
feed intake
Female
females
femelle
fertilidad
fertilite
fertility
gestacion
gestation
Growth Hormone - administration & dosage
Growth Hormone - pharmacology
health
hembra
human nutrition
ingestion de pienso
Lactation - drug effects
lait
leche
mammite bovine
mastitis bovina
methode d' application
metodos de aplicacion
milk
Milk - chemistry
milk yield
nutricion humana
nutrition humaine
Pregnancy
prise alimentaire animaux
Recombinant Proteins - administration & dosage
Recombinant Proteins - pharmacology
rendement laitier
rendimiento lechero
Reproduction
sanidad animal
sante animale
somatotropin
somatotropina
somatotropine
vacas lecheras
vache laitiere
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Summary:Lactating dairy cows (n = 264) were used in seven dose titration experiments at four geographic locations in the United States. A sustained-release formulation of recombinant bST was evaluated f or a 30-wk treatment period that began 14 wk postpartum. The first series of four experiments evaluated doses of 0, 140, 350, or 700mg of bST/14 d (series A); the second series evaluated doses of 0, 56, 140, or 350mg of bST/14 d (series B). Milk yield, DMI, milk composition, body condition, health, and reproductive parameters were measured. Multiparous cows in series A that were administered 700mg of bST/14 d yielded 3.0 kg/d more milk and 3.5% FCM than control cows. When all seven experiments were combined, multiparous cows that were administered 350mg of bST/14 d yielded 2.7 and 2.6 kg/d more milk and 3.5% FCM than control cows. Dry matter intake was not significantly affected by bST administration. In series A, an increase in milk yield with no increase in DMI resulted in lower adequacy of dietary NEL and CP to meet maintenance and yield requirements among multiparous cows administered 700mg of bST/14 d. Primiparous cows that were administered bST in series A and both parity groups in the combined seven experiments were not different from control cows in the adequacy of dietary NEL or CP or meet maintenance and yield requirements. No adverse effects of bST on health parameters were significant, and doses of 350mg of bST/14 d or less caused no changes in reproductive parameters. Conception rate was decreased by administration of 700mg of bST/14 d. These data suggest that 350mg of bST/14 d increased yields of milk and FCM with no adverse effects on DMI, health, or reproduction in dairy cows.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(93)77441-X