PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE: I. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp. OH-4652. These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex L...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1993/02/25, Vol.46(2), pp.222-228
Main Authors: OMURA, SATOSHI, PYL, DIDIER VAN DER, INOKOSHI, JUNJI, TAKAHASHI, YOKO, TAKESHIMA, HIDEO
Format: Article
Language:English
Subjects:
Alkyl and Aryl Transferases
Animals
Bacteria - drug effects
Cell Division - drug effects
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - metabolism
Enzyme Inhibitors - pharmacology
Fermentation
Microbial Sensitivity Tests
Oligopeptides - biosynthesis
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
Streptomyces
Streptomyces - classification
Streptomyces - metabolism
Transferases - antagonists & inhibitors
Vero Cells
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp. OH-4652. These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex LH-20 chromatography and reverse phase HPLC. Among these, pepticinnamin C showed the most potent inhibition (IC50-100nM).
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.222