DXS539, a polymorphic DNA marker proximal of the fragile-X gene

We report a new polymorphic DNA marker (pJH89, DXS539) proximal to the fragile-X site. The pJH89 probe identifies a TaqI and a NcoI restriction fragment length polymorphism (combined heterozygosity of 42%) and is linked to the fragile-X locus with a maximal LOD score of 12 at 4 cM. Multipoint linkag...

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Bibliographic Details
Published in:Human genetics 1993-03, Vol.91 (1), p.80-82
Main Authors: DREESEN, J. C. F. M, VAN DEN HURK, J. A. J. M, SMITS, A. P. T, VAN DEN OUWELAND, A. M. W, MARKSLAG, P. W. B, VAN OOST, B. A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Fragility
Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...)
DNA
Female
fragile sites
Fragile X Syndrome - genetics
Genetic Linkage - genetics
Genetic Markers
Humans
identification
Lod Score
Male
man
markers
Medical genetics
Medical sciences
Polymorphism, Genetic - genetics
restriction fragment length polymorphism
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Summary:We report a new polymorphic DNA marker (pJH89, DXS539) proximal to the fragile-X site. The pJH89 probe identifies a TaqI and a NcoI restriction fragment length polymorphism (combined heterozygosity of 42%) and is linked to the fragile-X locus with a maximal LOD score of 12 at 4 cM. Multipoint linkage analysis and physical mapping studies indicate that the pJH89 probe is located within in the interval defined by the markers DXS369 and DXS548.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00230229