Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for alle...

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Bibliographic Details
Published in:Nature (London) 1981-01, Vol.290 (5805), p.372-378
Main Authors: Coleclough, Christopher, Perry, Robert P, Karjalainen, Klaus, Weigert, Martin
Format: Article
Language:English
Subjects:
Alleles
Animals
B-Lymphocytes - immunology
Chromosome Deletion
Gene Expression Regulation
Immunoglobulin Fragments - genetics
Immunoglobulin Heavy Chains - genetics
Immunoglobulin kappa-Chains - genetics
Immunoglobulin lambda-Chains - genetics
Immunoglobulins - genetics
Leukemia, Experimental - immunology
Mice
Plasmacytoma - immunology
Recombination, Genetic
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Summary:A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
ISSN:0028-0836
1476-4687
DOI:10.1038/290372a0