Gastric cancer occurrence in preneoplastic lesions: A long‐term follow‐up in a high‐risk area in Spain

There are no established criteria to classify patients into high or low risk of progressing to gastric cancer (GC). The aim of the study was to identify predictors of GC occurrence among patients with gastric preneoplastic lesions. A prospective and retrospective follow‐up study was carried out in a...

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Bibliographic Details
Published in:International journal of cancer 2010-12, Vol.127 (11), p.2654-2660
Main Authors: González, Carlos A., Pardo, Maria Luisa, Ruiz Liso, Juan Maria, Alonso, Pablo, Bonet, Catalina, Garcia, Raul M., Sala, Núria, Capella, Gabriel, Sanz‐Anquela, José Miguel
Format: Article
Language:English
Subjects:
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Adult
Aged
Biological and medical sciences
Disease Progression
Female
Follow-Up Studies
follow‐up
gastric cancer
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Incidence
Male
Medical sciences
Middle Aged
Precancerous Conditions - epidemiology
Precancerous Conditions - pathology
preneoplastic lesions
Proportional Hazards Models
Prospective Studies
Retrospective Studies
Risk Factors
Spain - epidemiology
Stomach Neoplasms - epidemiology
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:There are no established criteria to classify patients into high or low risk of progressing to gastric cancer (GC). The aim of the study was to identify predictors of GC occurrence among patients with gastric preneoplastic lesions. A prospective and retrospective follow‐up study was carried out in a province in Spain with one of the highest risk of GC. The study included 478 patients who underwent gastric biopsy in 1988–1994 with diagnoses of normal mucosa, nonatrophic gastritis (NAG), non‐metaplastic multifocal atrophic gastritis (MAG) and complete or incomplete intestinal metaplasia (IM) and who accepted to undergo a new biopsy during 2005–2007 or had an event during follow up. Inter‐ and intra‐observer variability of histological diagnosis was assessed. Analysis was done using Cox proportional hazards risk (HR) models. The mean age of the patients was 50 years, 47% were males and the mean follow‐up time was 12.8 years. During follow‐up, 23 GC (4.8%) were diagnosed (21 adenocarcinomas and 2 lymphomas) with an incidence of 3.77 per 1,000 person per year. The incidence rate of GC for those with incomplete IM was 16.5 per 1,000 person years. Out the 21 adenocarcinomas, 16 had an incomplete IM in the baseline diagnosis. Incomplete IM (HR 11.3; 95% CI 3.8–33.9) and a family history of GC (HR 6.1; 95% CI 1.7–22.4) were the strongest risk factors for gastric adenocarcinoma. Subtyping of IM and family history of GC may be useful for the identification of high‐risk patients who need more intensive surveillance.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.25273