Naturally occurring deuterium is essential for the normal growth rate of cells

The role of naturally occurring D in living organisms has been examined by using deuterium-depleted water (30–40 ppm D) instead of water containing the natural abundance of D (150 ppm). The deuterium-depleted water significantly decreased the growth rate of the L 929 fibroblast cell line, and also i...

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Bibliographic Details
Published in:FEBS letters 1993-02, Vol.317 (1), p.1-4
Main Authors: Somlyai, Gábor, Jancsó, Gábor, Jákli, György, Vass, Kornélia, Barna, Balázs, Lakics, Viktor, Gaál, Tamás
Format: Article
Language:English
Subjects:
2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium-hydroxide
Adenocarcinoma
Animals
Biological and medical sciences
Body Water - physiology
Breast Neoplasms
Cell cycle, cell proliferation
Cell Division - physiology
Cell growth
Cell Line
Cell physiology
Culture Media, Serum-Free
Deuterium
Deuterium-depleted water
DMEM
Dulbeco's modified Eagle's media
Fundamental and applied biological sciences. Psychology
Humans
Hydrogen isotope discrimination
Isotope effect
Mice
Mice, Inbred CBA
Molecular and cellular biology
Na +H + antiport system
Neoplasm Transplantation
Tumor Cells, Cultured
XTT
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Summary:The role of naturally occurring D in living organisms has been examined by using deuterium-depleted water (30–40 ppm D) instead of water containing the natural abundance of D (150 ppm). The deuterium-depleted water significantly decreased the growth rate of the L 929 fibroblast cell line, and also inhibited the tumor growth in xenotransplanted mice. Eighty days after transplantation in 10 (59%) out of 17 tumorous mice the tumor, after having grown, regressed and then disappeared. We suggest that the naturally occurring D has a central role in signal transduction involved in cell cycle regulation.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(93)81479-J